Biotin-PEG7-amine
CAS No.: 1334172-76-7
Cat No.: BP-500542
Purity: >95%
4.5 
Biotin-PEG7-amine is a heterobifunctional PEG-based linker featuring a terminal biotin moiety connected through a polyethylene glycol chain to a primary amine. The PEG7 segment provides a flexible, hydrophilic spacer that reduces steric interference and helps maintain productive orientation between conjugated partners, while the biotin unit enables strong, high-affinity capture by streptavidin or avidin for assay readouts, immobilization, or enrichment workflows. In PROTAC and targeted protein degradation research, this linker is valuable as a modular attachment handle: the amine can be used for coupling to activated carboxyl groups, isothiocyanates, NHS-esters, or other electrophiles to incorporate the biotin-functionalized spacer into larger degradation constructs. The resulting biotin-tagged PROTAC or intermediate can facilitate purification, target engagement studies, and quantitative monitoring of conjugate integrity and cellular uptake, supporting reproducible experimental design.
Structure of 1334172-76-7
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Biotin-PEG7-amine is a PEG-based linker designed to connect biotin-tagged recognition elements to amine-reactive partners in targeted protein degradation (PROTAC) workflows. Its flexible poly(ethylene glycol) segment supports favorable linker conformations and improved solubility, while the terminal amine enables straightforward conjugation to electrophilic handles on ligands. The biotin functionality can also facilitate affinity-based handling or capture during PROTAC assembly and characterization. Detailed structural and reactivity considerations are provided below.
Structure: Biotin-PEG7-amine comprises a biotin moiety tethered through a flexible poly(ethylene glycol) chain terminating in a primary amine. The linker contains ether linkages within the PEG backbone, an amide-bearing biotin scaffold, and a terminal C–N bond suitable for nucleophilic coupling. Overall, it is typically water-compatible and conformationally adaptable.
Reactivity: The terminal primary amine is suited for coupling reactions commonly used in PROTAC synthesis, including amide bond formation with activated carboxylic acids (e.g., via carbodiimide activation) and nucleophilic substitution on electrophilic intermediates. Reactions are generally performed under mild, anhydrous or buffered conditions compatible with PEG stability, using standard coupling reagents and bases in polar aprotic solvents. Mechanistically, nucleophilic attack by the amine on an activated carbonyl or leaving group drives bond formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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