NH2-PEG8-C1-Boc
Cat No.: BP-501866
4.5 
NH2-PEG8-C1-Boc is a polyethylene glycol–based PROTAC linker featuring a terminal primary amine for controlled conjugation and a Boc-protected functional handle that can be deprotected to enable subsequent coupling chemistry. The PEG8 chain provides a flexible, hydrophilic spacer that can reduce steric interference between a ligand-binding “warhead” and an E3 ligase recruiter, while also improving aqueous solubility and conformational adaptability in ternary complex formation. In PROTAC architectures, such linkers are used to tune the effective distance and relative orientation of the two binding moieties, thereby influencing cooperativity and degradation potency. The Boc group offers practical synthetic utility by temporarily masking reactivity during multi-step assembly, supporting reproducible linker installation and purification. This product is valuable for researchers optimizing targeted protein degradation constructs, particularly when spacer flexibility and orthogonal functional group management are critical for achieving robust, experimentally verifiable degradation activity.
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* For research and manufacturing use only. Not for human or clinical use.
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NH2-PEG8-C1-Boc, is a polyethylene glycol–based, amine-functionalized scaffold bearing a Boc-protected handle for controlled conjugation. Its flexible, hydrophilic PEG segment can improve solubility and accommodate the spatial requirements typical of targeted protein degradation constructs. The protected amine enables stepwise assembly, supporting reliable synthesis workflows for PROTACs; detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG ether chain that provides conformational flexibility and hydrophilicity, coupled to a terminal primary amine functionality. A Boc protecting group is present to suppress undesired side reactions during coupling steps. Ether linkages dominate the backbone, with carbamate formation associated with Boc protection.
Reactivity: The Boc group can be selectively removed under standard acidolysis conditions to reveal the free amine for subsequent amide or carbamate-forming couplings. PROTAC assembly commonly uses nucleophilic acyl substitution strategies, where the deprotected amine is reacted with activated carboxylic acid derivatives. Suitable conditions typically employ coupling reagents and polar aprotic solvents, with reaction monitoring to ensure efficient conversion and minimize PEG-related side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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