Boc-PEG8-Boc

 CAS No.: 1432970-18-7  Cat No.: BP-500994 4.5  

Boc-PEG8-Boc is a homobifunctional polyethylene glycol linker bearing Boc-protected carboxylate groups at both termini, connected through an extended octaethylene glycol spacer. This symmetric architecture provides a versatile building block for PROTAC construction, where both Boc groups can be removed under standard acidic conditions, either simultaneously or sequentially, to reveal two free carboxylic acids for amide coupling with primary amine-containing ligands. The extended PEG chain confers substantial aqueous solubility and high conformational flexibility, both critical for accommodating the large intermolecular distances required for productive ternary complex formation between certain target proteins and E3 ubiquitin ligases. In PROTAC design, linker length is a critical determinant of degradation efficiency, and this compound represents the longer end of the homologous bis-Boc PEG series, enabling researchers to explore the conformational space accessible with extended, high-flexibility linkers. The symmetric, bis-protected design simplifies synthetic workflows and enables the construction of symmetric or asymmetric PROTAC architectures through sequential deprotection and coupling. Researchers utilize this linker to systematically investigate how extended PEG spacer lengths influence degradation potency, selectivity, and physicochemical properties in targeted protein degradation research.

Structure of 1432970-18-7

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PROTAC Linker

Molecular Formula

C₂₈H₅₄O₁₃

Molecular Weight

598.72

* For research and manufacturing use only. Not for human or clinical use.

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