Butoxycarbonyl-PEG5-sulfonic acid
CAS No.: 1817735-28-6
Cat No.: BP-500882
4.5 
Butoxycarbonyl-PEG5-sulfonic acid is a PEG-based linker bearing a terminal sulfonic acid group and a butoxycarbonyl (carbamate) protecting/functional handle. Structurally, it consists of a short, five–ethylene glycol unit flexible spacer that provides aqueous solubility and conformational freedom, while the sulfonate offers a strongly polar, anionic interaction handle and the carbamate enables controlled coupling strategies to attach to electrophilic partners (e.g., activated carboxylates or amines) or to tune linker chemistry during PROTAC assembly. In PROTAC design, PEG linkers are widely used to spatially separate the ligand-binding modules from the recruitment moiety, reducing steric interference and improving productive formation of the ternary complex with the target protein and E3 ligase. This linker is valuable for researchers seeking robust, water-compatible conjugation scaffolds that can be systematically varied to optimize degradation potency, cooperativity, and overall physicochemical properties in targeted protein degradation experiments.
Structure of 1817735-28-6
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Butoxycarbonyl-PEG5-sulfonic acid is a PEG-based PROTAC linker component designed to provide a hydrophilic, conformationally flexible spacer between a targeting ligand and an E3-recruiting moiety. Its sulfonic acid functionality supports robust conjugation strategies and improved aqueous compatibility, while the PEG segment helps reduce steric bias and can enhance effective ternary complex formation. The detailed structural and synthetic considerations for PROTAC construction are described below.
Structure: The molecule contains a butoxycarbonyl-protected carbonyl unit connected to a PEG chain terminated by a sulfonic acid. Ether linkages in the PEG segment confer flexibility and polarity, while the sulfonate group provides strong ionic character. Overall, it behaves as a water-compatible, functionalized linker for bioconjugation.
Reactivity: The sulfonic acid terminus enables formation of activated derivatives suitable for coupling to amine- or hydroxyl-bearing partners under standard bioconjugation conditions. For PROTAC assembly, researchers commonly employ carboxyl/acid activation strategies and subsequent nucleophilic substitution to connect ligands without disrupting sensitive functional groups. Mild aqueous or mixed-solvent systems and coupling reagents used for sulfonate/acid activation are typically selected to preserve linker integrity and maintain reproducible yields.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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