Carboxy-PEG2-sulfonic acid
CAS No.: 1817735-45-7
Cat No.: BP-500547
Purity: ≥95%
4.5 
Carboxy-PEG2-sulfonic acid is a short, water-soluble polyethylene glycol (PEG) linker bearing both a terminal carboxylic acid and a sulfonic acid group. Structurally, it provides a compact, highly polar spacer that can be used to tune solubility, reduce nonspecific hydrophobic interactions, and control the effective distance and orientation between PROTAC-relevant binding elements. In targeted protein degradation constructs, such bifunctional handles enable straightforward conjugation or coupling to other PROTAC components (e.g., attaching to ligand-derived amines or activating the carboxyl group for amide formation), while the PEG segment helps maintain productive geometry for ternary complex formation. Its dual acidic functionality also supports aqueous handling and can improve formulation stability during synthesis and biological testing. Overall, this linker is valuable for researchers optimizing linker length, hydrophilicity, and conjugation chemistry in PROTAC and related targeted degradation studies.
Structure of 1817735-45-7
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Carboxy-PEG2-sulfonic acid is a bifunctional polyethylene glycol-based linker designed to support PROTAC assembly by providing a hydrophilic spacer and orthogonal reactive handles for conjugation. Its PEG character can help modulate solubility and reduce local steric congestion between the ligand and the recruited E3 ligase, supporting efficient formation of productive ternary complexes. The structural and synthetic considerations for using this linker in targeted protein degradation workflows are detailed below.
Structure: The linker contains a PEG-based ethylene glycol segment bearing a carboxylic acid and a sulfonic acid functionality. It features polar ether linkages that confer hydrophilicity, along with strong acid groups capable of ionic interactions. Overall, it behaves as a water-compatible, highly polar scaffold suitable for conjugation chemistry.
Reactivity: The carboxylic acid can be activated for amide or ester bond formation under standard coupling protocols, commonly using carbodiimide-based activators with auxiliary reagents to promote efficient ester/amide formation. The sulfonic acid is typically retained as a stable, strongly acidic group and is generally not the site of coupling. Suitable solvents include polar aprotic media, with conditions chosen to preserve PEG integrity and minimize side reactions during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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