Fmoc-aminooxy-PEG12-acid
Cat No.: BP-501740
4.5 
Fmoc-aminooxy-PEG12-acid is a polyethylene glycol-based PROTAC linker featuring an Fmoc-protected aminooxy (O-alkoxy) functionality at one terminus and a terminal carboxylic acid at the other. The PEG12 segment provides a flexible, hydrophilic spacer that can reduce steric interference and improve productive positioning of conjugated ligands in ternary-complex formation. In targeted protein degradation constructs, the aminooxy group enables chemoselective oxime/oxime-ether formation with aldehyde-bearing partners, allowing researchers to connect this linker to targeting or E3-recruiting modules under mild conditions, while the carboxylic acid supports further coupling to activated derivatives (e.g., amide formation) for modular assembly. This linker is therefore valuable for building well-defined PROTAC architectures where controlled distance, solubility, and conjugation chemistry are critical for efficient degradation and for systematic structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Fmoc-aminooxy-PEG12-acid is a PEG-based bifunctional linker designed for constructing PROTACs and related targeted protein degradation conjugates. Its aminooxy handle enables oxime formation with suitable carbonyl-bearing ligands, while the carboxylic acid provides a robust attachment point for coupling strategies. The PEG spacer supports favorable solubility and conformational flexibility, which can improve linker accessibility and degradation performance. The following sections describe the structure and practical reactivity considerations in detail.
Structure: The linker contains a poly(ethylene glycol) chain providing a hydrophilic, flexible spacer, flanked by an Fmoc-protected aminooxy functionality and a terminal carboxylic acid. It features ether linkages within the PEG backbone, an aminooxy group for oxime chemistry, and aromatic carbamate protection associated with Fmoc.
Reactivity: PROTAC assembly typically uses the aminooxy group to form stable oxime linkages with aldehyde or ketone partners under mildly acidic to neutral conditions, often employing an aniline or related nucleophilic catalyst to accelerate oxime formation. The terminal carboxylic acid can be activated for amide coupling using standard coupling reagents in aqueous or mixed organic solvents. Fmoc deprotection, when required, is commonly performed with base prior to further conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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