Fmoc-N-amido-PEG1-acid

 CAS No.: 1654740-73-4  Cat No.: BP-501196  Purity: >98% 4.5  

Fmoc-N-amido-PEG1-acid is a PEG linker containing a Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under the basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Fmoc-N-amido-PEG1-acid

Structure of 1654740-73-4

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Category
PROTAC Linker
Molecular Formula
C20H21NO5
Molecular Weight
355.38
Appearance
Pale Yellow or Colorless Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
>98%
Solubility
Soluble in DMSO
Appearance
Pale Yellow or Colorless Oily Matter
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]propanoic acid
Synonyms
Fmoc-6-Amino-4-oxahexanoic acid; Fmoc-N-amido-PEG1-acid; Fmoc-NH-PEG1-C2-acid; Fmoc-NH-PEG1-CH2CH2COOH; 6-(Fmoc-amino)-4-oxahexanoic Acid; Fmoc-AEP; Fmoc-PEG1-propionic acid; Propanoic acid, 3-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]-; 3-[2-(Fmoc-amino)ethoxy]propanoic acid
Boiling Point
589.9±40.0 °C at 760 mmHg
Density
1.261±0.06 g/cm3 (Predicted)
InChI Key
LHBCOPWWQKLECJ-UHFFFAOYSA-N
InChI
InChI=1S/C20H21NO5/c22-19(23)9-11-25-12-10-21-20(24)26-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,18H,9-13H2,(H,21,24)(H,22,23)
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCC(=O)O

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: Amino-PEG12-CH2-Boc | Carboxy-PEG4-phosphonic acid | Amino-PEG6-amine | Fmoc-N-amido-PEG1-acetic acid | LC-SMPH | Azido-PEG1-C2-methylamine | HO-PEG17-OH | Azido-PEG3-O-NHS ester | mPEG8-NH-Mal | Tetrakis-(N-succinimidylcarboxypropyl)pentaerythritol | Fmoc-N-amido-PEG1-acid

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