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Fmoc-N-amido-PEG1-acid - CAS 1654740-73-4

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Fmoc-N-amido-PEG1-acid is a PEG linker containing a Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under the basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

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Molecular Formula
C20H21NO5
Molecular Weight
355.38

Fmoc-N-amido-PEG1-acid

    • Specification
      • Related CAS
        850312-72-0 (polymer)
        Purity
        >98%
        Solubility
        Soluble in DMSO
        Appearance
        Pale Yellow or Colorless Oily Matter
        Storage
        Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
        Shipping
        Room temperature in continental US; may vary elsewhere.
        IUPAC Name
        3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]propanoic acid
        Synonyms
        Fmoc-6-Amino-4-oxahexanoic acid; Fmoc-N-amido-PEG1-acid; Fmoc-NH-PEG1-C2-acid; Fmoc-NH-PEG1-CH2CH2COOH; 6-(Fmoc-amino)-4-oxahexanoic Acid; Fmoc-AEP; Fmoc-PEG1-propionic acid; Propanoic acid, 3-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]-; 3-[2-(Fmoc-amino)ethoxy]propanoic acid
    • Properties
      • Boiling Point
        589.9±40.0 °C at 760 mmHg
        Density
        1.261±0.06 g/cm3 (Predicted)
        InChI Key
        LHBCOPWWQKLECJ-UHFFFAOYSA-N
        InChI
        InChI=1S/C20H21NO5/c22-19(23)9-11-25-12-10-21-20(24)26-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,18H,9-13H2,(H,21,24)(H,22,23)
        Canonical SMILES
        C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCC(=O)O
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