3-(2-(benzyloxy)ethoxy)propan-1-ol

3-(2-(benzyloxy)ethoxy)propan-1-ol, provides a flexible, ether-rich scaffold with a terminal primary alcohol handle suitable for conjugation to targeting ligands and E3-recruiting modules. Its benzyloxy-protected ethoxy segment supports controlled synthetic staging, while the hydroxyl functionality enables robust derivatization strategies used in PROTAC construction. The

Structure: The linker contains an aliphatic propanol core bearing an ether chain and a benzyloxy-protected ethoxy substituent. It features C–O ether and C–O alcohol bonds, aromatic benzyl ether linkage, and a terminal primary alcohol that can be selectively functionalized. Overall, it is an oxygen-rich, conformationally flexible organic scaffold.

Reactivity: The terminal primary alcohol can be converted to activated intermediates for coupling to PROTAC components via esterification or ether formation, commonly using carbodiimide-based coupling systems for carboxyl partners or alkylation/halide substitution strategies for nucleophiles. The benzyloxy group is typically stable under mild conditions but can be removed by hydrogenolysis or strong acid to reveal additional hydroxyl functionality. Solvent choice and protection compatibility should be optimized to preserve ligand integrity.