Name: mPEG2-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature, or blue ice upon request.

IUPACName

2-(2-methoxyethoxy)ethanamine

Synonyms

m-PEG2-amine; 1-(2-aminoethoxy)-2-methoxyethane; mPEG2-NH2; Ethanamine, 2-(2-methoxyethoxy)-; 2-(2-methoxyethoxy)ethan-1-amine; NH2-PEG2-OME; MeO-PEG(2)-NH2

Boiling Point

163.7±15.0 °C at 760 mmHg

Density

0.934±0.06 g/cm3 (Predicted)

InChI Key

QWCGXANSAOXRFE-UHFFFAOYSA-N

InChI

InChI=1S/C5H13NO2/c1-7-4-5-8-3-2-6/h2-6H2,1H3

SMILES

COCCOCCN

Biological Activity

m-PEG2-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

This mPEG2-amine linker is designed for modular conjugation in PROTAC architectures, enabling flexible attachment of ligands through a terminal primary amine. Its poly(ethylene glycol) character supports improved solubility and reduced nonspecific interactions, which can benefit cellular delivery and assay performance. The linker’s functional group compatibility makes it broadly useful for constructing targeted protein degraders, and the following sections describe its structure and practical reactivity for PROTAC synthesis.

Structure: The material comprises a short methoxy-terminated poly(ethylene glycol) chain bearing a terminal primary amine. It contains ether linkages along the PEG backbone and an amine at the terminus, providing a polar, hydrogen-bonding functional handle for coupling reactions. Overall, it is typically water-compatible and nonvolatile.

Reactivity: The terminal primary amine can be used to form stable amide or urea linkages with activated carboxylic acids or isocyanates, or to participate in reductive amination with aldehydes under standard organic synthesis conditions. Common approaches employ coupling reagents for carboxyl activation, with polar aprotic solvents and mild bases to maintain amine reactivity while minimizing PEG chain degradation. Reaction monitoring by LC or NMR is recommended to confirm completion and minimize side products.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂