mPEG2-amine

 CAS No.: 31576-51-9  Cat No.: BP-500154  Purity: ≥95% 4.5  

mPEG2-amine is a short PEG linker with terminal amine functionality, used for efficient conjugation in ADC linker design. Its PEG2 spacer improves aqueous solubility and helps reduce immunogenicity in antibody-drug conjugates and other bioconjugate systems.

mPEG2-amine

Structure of 31576-51-9

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Category
PROTAC Linker
Molecular Formula
C5H13NO2
Molecular Weight
119.16
Appearance
Pale Yellow or Colorless Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Appearance
Pale Yellow or Colorless Oily Matter
Storage
Store at 2-8°C
Shipping
Room temperature, or blue ice upon request.
IUPACName
2-(2-methoxyethoxy)ethanamine
Synonyms
m-PEG2-amine; 1-(2-aminoethoxy)-2-methoxyethane; mPEG2-NH2; Ethanamine, 2-(2-methoxyethoxy)-; 2-(2-methoxyethoxy)ethan-1-amine; NH2-PEG2-OME; MeO-PEG(2)-NH2
Boiling Point
163.7±15.0 °C at 760 mmHg
Density
0.934±0.06 g/cm3 (Predicted)
InChI Key
QWCGXANSAOXRFE-UHFFFAOYSA-N
InChI
InChI=1S/C5H13NO2/c1-7-4-5-8-3-2-6/h2-6H2,1H3
Canonical SMILES
COCCOCCN
Biological Activity
m-PEG2-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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It is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Tetrazine-Ph-NHCO-PEG3-alcohol | Tetrazine-Ph-PEG5-Ph-tetrazine | m-PEG17-Hydrazide | t-Boc-N-amido-PEG7-amine | 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine | N-Mal-N-bis(PEG2-acid) | Bis-PEG7-PFP ester | Propargyl-PEG3-OCH2-Boc | I-PEG6-OH | Azide-PEG9-amido-C16-Boc | Boc-Aminooxy-PEG3-bromide

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