Folate-PEG1-mal
Cat No.: BP-501918
4.5 
Folate-PEG1-mal is a heterobifunctional PROTAC linker built on a short polyethylene glycol spacer bearing a terminal maleimide (mal) for selective conjugation and a folate recognition motif for targeting folate-receptor–expressing systems. Structurally, it combines a folate headgroup with a PEG1 chain that provides modest hydrophilicity and spatial separation, while the maleimide electrophile enables chemoselective coupling to thiol-containing partners (for example, cysteine residues or thiol-functionalized ligands) via stable thioether bond formation. In PROTAC or targeted degradation workflows, this linker can be used to tether a folate-based targeting ligand to a second module, such as an E3 ligase binder or a reactive handle-bearing degrader scaffold, thereby promoting proximity-driven recruitment and facilitating ternary-complex formation. Its value lies in enabling modular assembly of folate-receptor–directed degraders with controlled conjugation chemistry and reduced steric interference, supporting systematic structure–activity optimization in targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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This Folate-PEG1-mal linker is designed to connect a folate-derived targeting motif to a PROTAC-relevant functional handle, enabling efficient assembly of targeted protein degraders through modular conjugation. Its PEG-based spacer supports favorable solubility and conformational flexibility, while the malemide functionality provides a robust platform for forming stable linkages under standard bioconjugation practices. The sections below describe the linker’s structure and the practical reactivity considerations for PROTAC construction.
Structure: The linker contains a short polyethylene glycol spacer that confers hydrophilicity and spacing between conjugated fragments. It incorporates a malemide (maleimide) electrophilic group capable of selective nucleophile addition, alongside a folate-derived targeting element for receptor-mediated recognition. The scaffold features stable covalent linkages suitable for PROTAC assembly.
Reactivity: Malemide groups typically undergo Michael-type addition with thiol-containing nucleophiles, enabling conjugation to cysteine-bearing ligands or thiolated intermediates. For PROTAC synthesis, reactions are commonly performed under mildly basic, aqueous or mixed-solvent conditions to maintain thiol nucleophile availability while minimizing side reactions. Solvent systems that preserve solubility of both partners are preferred, and catalysts are generally not required; careful control of pH and thiol stoichiometry supports selective coupling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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