Hydroxy-PEG12-CH2-Boc
Cat No.: BP-501831
4.5 
Hydroxy-PEG12-CH2-Boc is a functionalized polyethylene glycol (PEG) linker featuring a terminal hydroxyl group and a methylene (CH2) spacer terminating in a tert-butyl ester-protected carboxyl group. The PEG segment provides a flexible, water-compatible chain length that can reduce steric interference and improve solubility of PROTAC constructs, while the CH2/tert-butyl ester handle enables controlled conjugation chemistry during linker assembly. In PROTAC design, such linkers serve as molecular “spacers” that position an E3 ligase ligand and a target-binding ligand at an appropriate distance and relative orientation to promote formation of a productive ternary complex. The hydroxyl functionality supports further derivatization or coupling strategies, and the tert-butyl ester can be selectively deprotected to reveal a carboxylic acid without perturbing other groups. This product is valuable for researchers optimizing linker length, flexibility, and conjugation compatibility in targeted protein degradation experiments, where systematic tuning of linker architecture often correlates with changes in binding cooperativity and degradation potency.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Hydroxy-PEG12-CH2-Boc is a polyethylene glycol-based PROTAC linker featuring a hydroxyl terminus for controlled functionalization and a tert-butyl ester-protected carboxyl handle for orthogonal coupling strategies. Its flexible PEG scaffold can improve solubility and provide conformational adaptability between target-binding and E3-ligase ligands. In PROTAC workflows, this linker is commonly used to assemble degraders through stepwise, chemoselective reactions, enabling systematic tuning of linker length and attachment chemistry. Detailed structural and reactivity guidance is provided below.
Structure: The molecule contains a PEG chain with terminal hydroxyl functionality and a methylene spacer, combined with a tert-butyl ester-protected carboxyl group. It is characterized by ether linkages along the PEG backbone, a flexible polyether segment, and ester chemistry associated with tert-butyl carboxyl protection, supporting favorable solvation behavior.
Reactivity: The tert-butyl ester is typically cleaved under mild acid conditions to generate the carboxylic acid for subsequent activation and coupling, while the hydroxyl group can be converted to activated derivatives for nucleophilic substitution or ester formation. Linker installation in PROTACs often follows orthogonal protection/deprotection logic, using standard coupling chemistries (e.g., carbodiimide-mediated ester/amidation) in compatible solvents. Reaction design should preserve PEG integrity and avoid conditions that degrade the polyether chain.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
