Name: Lipoamido-PEG4-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Appearance

Light Yellow or White Solid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-(2-(2-(2-(2-(5-(1,2-dithiolan-3-yl)pentanamido)ethoxy)ethoxy)ethoxy)ethoxy)propanoic acid

Synonyms

Lipoamido-PEG4-CH2CH2COOH; LA-PEG4-COOH; Lipoamido-PEG4-COOH; 3-[2-[2-[2-[2-[5-(dithiolan-3-yl)pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid; 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo-; 21-(1,2-Dithiolan-3-yl)-17-oxo-4,7,10,13-tetraoxa-16-azahenicosan-1-oic acid

Density

1.2±0.1 g/cm3

InChI Key

QJFPDZROPSGMGV-UHFFFAOYSA-N

InChI

InChI=1S/C19H35NO7S2/c21-18(4-2-1-3-17-6-16-28-29-17)20-7-9-25-11-13-27-15-14-26-12-10-24-8-5-19(22)23/h17H,1-16H2,(H,20,21)(H,22,23)

SMILES

C1CSSC1CCCCC(=O)NCCOCCOCCOCCOCCC(=O)O

Lipoamido-PEG4-acid is a PEG-based linker designed to connect a lipid-like moiety to a terminal carboxylic acid, enabling flexible spacing and improved conjugation compatibility in targeted protein degradation constructs. Its hydrophilic PEG segment supports solubility and conformational adaptability, while the acid handle facilitates robust amide or ester-forming coupling to ligands used in PROTAC architectures. The detailed structural and reactivity considerations are provided below for researchers planning linker installation and PROTAC assembly.

Structure: The linker contains a PEG chain segment flanked by an amide (lipoamido) linkage and a terminal carboxylic acid. It features stable covalent amide bonds and an acid group capable of forming activated intermediates. The PEG portion imparts hydrophilicity and conformational flexibility, supporting aqueous compatibility in conjugation workflows.

Reactivity: The terminal carboxylic acid is suitable for standard PROTAC linker coupling via amide-bond formation using carboxyl activation reagents (for example, carbodiimides with coupling additives) under controlled base and temperature conditions. Alternatively, acid activation followed by nucleophilic substitution can furnish ester intermediates when desired. These transformations proceed through formation of an activated ester/amide intermediate, typically in polar aprotic solvents, enabling attachment to amine-bearing ligands used for targeted degradation.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂