m-PEG16-azide
Cat No.: BP-501783
Purity: 98%
4.5 
m-PEG16-azide is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal azide group, providing a flexible, water-soluble chain of intermediate length suitable for bioconjugation workflows. The PEG backbone acts as a spacer that reduces steric interference and improves solubility of PROTAC constructs, while the azide handle enables chemoselective attachment to complementary alkyne-containing partners via copper-free or copper-catalyzed azide–alkyne cycloaddition. In targeted protein degradation design, this linker can be positioned between a ligand for an E3 ligase and a ligand for the target protein to tune effective distance, relative orientation, and overall degrader pharmacophore geometry, thereby influencing ternary complex formation and degradation potency. Its practical value lies in facilitating modular synthesis and rapid library generation of degraders, allowing researchers to systematically vary linker length and attachment chemistry while maintaining aqueous compatibility for in vitro assays.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG16-azide is a polyethylene glycol (PEG)-based azide linker designed to support modular assembly of PROTAC constructs. Its flexible, hydrophilic PEG scaffold helps tune solubility and spatial presentation between the targeting and recruiting ligands, which can improve effective ternary complex formation. The azide handle enables efficient bioorthogonal conjugation strategies commonly used in targeted protein degradation workflows. Detailed structural and reactivity guidance is provided below.
Structure: The linker comprises a meta-substituted PEG chain terminating in an azide functional group. It contains repeating ether linkages that confer conformational flexibility and strong hydrogen-bonding interactions with water. The terminal azide provides a chemically distinct, reactive group for selective coupling while the PEG backbone remains electronically and sterically adaptable.
Reactivity: The azide group is well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling attachment to alkyne-bearing ligands under mild, orthogonal conditions. Typical PROTAC assembly uses polar solvents compatible with both components, with copper catalysts and appropriate ligands for CuAAC or catalyst-free conditions for SPAAC. Mechanistically, cycloaddition proceeds via formation of a triazole linkage, preserving linker integrity and enabling modular synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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