Name: m-PEG2-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-(2-methoxyethoxy)propanoic acid

Synonyms

Propanoic acid, 3-(2-methoxyethoxy)-; m-PEG2-acid; mPEG1-OCH2CH2COOH; MeOCH2CH2OCH2COOH; methoxy-PEG1-Propionic acid

Boiling Point

244.2±20.0°C (Predicted)

Density

1.098±0.06 g/cm3 (Predicted)

InChI Key

KWMXBFIAGYXCCC-UHFFFAOYSA-N

InChI

InChI=1S/C6H12O4/c1-9-4-5-10-3-2-6(7)8/h2-5H2,1H3,(H,7,8)

SMILES

COCCOCCC(=O)O

m-PEG2-COOH is a compact methoxy PEG acid linker suitable for introducing limited hydrophilic spacing into PROTAC molecules. Its short ether segment helps tune polarity without excessive linker extension, while the carboxyl terminus supports robust ligand coupling. The structure and reactivity are described below.

Structure: The linker contains a methoxy-capped oligoethylene glycol segment and a terminal carboxylic acid. It is non-aromatic, polar, and conformationally mobile, with ether bonds and an acid functionality.

Reactivity: The acid terminus is suited to amide formation with amine-bearing ligands after activation by common peptide-coupling reagents. Activated ester preparation is also applicable for staged conjugation. Mild base, dry polar solvents, and moisture control help improve coupling efficiency while limiting hydrolysis of activated intermediates.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂