N-(m-PEG4)-N'-(azide-PEG3)-Cy5
CAS No.: 2107273-02-7
Cat No.: BP-501603
Purity: 97%
4.5 
N-(m-PEG4)-N'-(azide-PEG3)-Cy5 is a PEG–Cy5 conjugate featuring a Cy5 fluorophore bearing a methoxy-terminated PEG4 segment and an azide-terminated PEG3 chain. The linker architecture combines a methoxy-capped PEG4 segment with a terminal azide handle for bioorthogonal coupling via strain-promoted or copper-catalyzed azide–alkyne cycloaddition. In PROTAC and targeted-degradation workflows, this fluorescent PEGylated design enables modular attachment of a fluorescent reporter to either the recruiting ligand or the E3-binding moiety, while preserving solubility and reducing nonspecific interactions through the PEG spacers. Its value lies in facilitating real-time tracking of conjugate assembly, monitoring cellular uptake and localization, and quantifying degradation-related binding events using fluorescence readouts, thereby improving experimental design and optimization for targeted protein degradation studies.
Structure of 2107273-02-7
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker reagent, N-(m-PEG4)-N'-(azide-PEG3)-Cy5, integrates a Cy5 fluorophore with orthogonally addressable PEG segments and an azide handle. Its flexible, hydrophilic architecture supports solubility and reduced nonspecific interactions, while the azide enables reliable bioorthogonal conjugation steps commonly used in PROTAC assembly workflows. The subsequent points describe the structural features and practical reactivity considerations for constructing targeted protein degraders.
Structure: The molecule contains a Cy5 chromophore substituted with polyethylene glycol chains, combining aromatic photophysics with a flexible PEG scaffold. An azide group is presented on a PEG terminus, providing a distinct functional handle for click-type coupling. The overall structure is highly polar and water-compatible.
Reactivity: The azide functionality is suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling modular attachment of targeting ligands and/or warheads under mild, aqueous-compatible conditions. Typical implementations use appropriate alkyne partners, with CuAAC requiring copper and a stabilizing ligand to control reactivity, while SPAAC avoids copper. Reaction progress is commonly monitored by fluorescence and conjugation-specific analytical methods.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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