m-PEG4-CH2-methyl ester
CAS No.: 1920109-55-2
Cat No.: BP-501109
Purity: ≥95%
4.5 
m-PEG4-CH2-methyl ester is a polyethylene glycol (PEG)–based PROTAC linker featuring a methoxy-terminated PEG4 chain and a methyl ester at the opposite end, providing a flexible, hydrophilic spacer between conjugation partners. The PEG segment increases aqueous solubility and helps reduce steric and electrostatic penalties that can impair formation of productive ternary complexes in targeted protein degradation. The methyl ester is typically hydrolyzed to the corresponding carboxylic acid before activation and coupling, while the methoxy terminus remains a nonreactive cap. In PROTAC design, this type of PEG linker can tune the effective distance and conformational freedom between the recruiting moiety and the target-binding ligand, thereby influencing ubiquitin-recruiting efficiency and degradation potency. As a modular building block, it is valuable for constructing and optimizing linker architectures in experimental targeted degradation workflows, facilitating systematic structure–activity relationship studies.
Structure of 1920109-55-2
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m-PEG4-CH2-methyl ester is a polyethylene glycol-based PROTAC linker building block designed to provide solubility, conformational flexibility, and efficient spatial separation between targeting and recruiting ligands. Its ester functionality enables modular conjugation strategies commonly used in targeted protein degradation workflows. The subsequent points describe the linker’s structural features and practical considerations for assembling PROTAC constructs in research settings.
Structure: The linker comprises a methoxy-terminated PEG chain bearing a methylene-linked methyl ester at the opposite terminus. It contains repeating ether linkages that confer hydrophilicity and flexibility, alongside a methyl ester that can be converted to a carboxylic acid for further derivatization. Overall polarity supports aqueous compatibility for PROTAC synthesis and handling.
Reactivity: The methyl ester is commonly hydrolyzed to the corresponding carboxylic acid before amide coupling to an amine-bearing ligand, rather than being treated as an activated ester. After hydrolysis, typical approaches use standard carboxyl-activation coupling reagents, with polar aprotic solvents to maintain solubility. Mechanistically, carboxyl activation followed by nucleophilic attack from an amine-bearing partner yields a stable amide linkage for PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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