m-PEG6-C6-phosphonic acid ethyl ester
CAS No.: 2028281-88-9
Cat No.: BP-501592
Purity: ≥95%
4.5 
m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker featuring an oligo(ethylene glycol) chain of intermediate length connected to a C6 aliphatic spacer and terminated with a phosphonate protected as an ethyl ester. The linker’s ether-rich PEG segment provides conformational flexibility and improved aqueous compatibility, while the C6 spacer helps spatially separate the two conjugation handles to reduce steric interference during ternary-complex formation. The phosphonate ethyl ester serves as a chemically addressable functional group for assembling PROTAC architectures, enabling attachment to targeting ligands or E3-recruiting moieties through appropriate coupling strategies, and can be further converted to the corresponding phosphonic acid for stronger, more defined interactions with phosphophilic binding motifs when required. In targeted protein degradation research, such linkers are valuable for tuning linker length, polarity, and geometry to optimize degradation potency, selectivity, and cellular stability.
Structure of 2028281-88-9
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based, flexible linker designed to support targeted protein degradation workflows by connecting a ligand scaffold to an E3-recruiting or binding module in PROTAC constructs. Its ether-rich PEG segment can improve solubility and conformational adaptability, while the phosphonate handle enables robust synthetic diversification. The combination of hydrophilic spacing and a chemically addressable phosphonate functionality makes this linker suitable for assembling degraders that require controlled linker length and reliable coupling chemistry. Detailed structure and reactivity considerations are provided below.
Structure: The linker contains a polyethylene glycol chain linked to a C6 spacer and terminates in a phosphonic acid ethyl ester. It features multiple ether linkages, an alkyl spacer segment, and a phosphonate ester group, providing a polar, hydrogen-bond-accepting framework with enhanced aqueous compatibility.
Reactivity: The phosphonate ethyl ester enables phosphorylation-related transformations commonly used in PROTAC linker synthesis, including ester hydrolysis to the free phosphonic acid and subsequent coupling to electrophiles or activated partners. Typical approaches rely on controlled acid or base catalysis for deprotection, followed by standard phosphonate coupling strategies under inert or moisture-controlled conditions. Solvent systems are selected to maintain PEG solubility and preserve sensitive functional groups during stepwise assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
