m-PEG9-Boc
Cat No.: BP-501899
4.5 
m-PEG9-Boc is an m-methoxy-terminated polyethylene glycol linker bearing a terminal tert-butyl ester-protected carboxyl group, providing a flexible, water-compatible spacer for assembling PROTACs and other targeted degradation constructs. The PEG segment acts as a hydrophilic, conformationally dynamic tether that can reduce steric interference between the ligand warhead and the E3-recruiting moiety, while the tert-butyl ester protects the carboxyl group for subsequent deprotection and coupling under standard synthetic conditions. In PROTAC design, such linkers are used to tune effective distance and relative orientation, thereby improving productive ternary complex formation and facilitating efficient ubiquitination of the target protein. As a modular building block, m-PEG9-Boc supports systematic linker-length and chemistry optimization, enabling researchers to evaluate how spacer flexibility and terminal functionality influence degradation potency, selectivity, and solubility in biochemical and cellular assays.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG9-Boc is a polyethylene glycol-based PROTAC linker building block designed to provide solubility, conformational flexibility, and a protected functional handle for stepwise assembly of targeted protein degradation constructs. Its PEG segment can help improve aqueous compatibility and reduce aggregation during synthesis and biological handling, while the Boc-protected group enables controlled downstream functionalization. The detailed structural and synthetic considerations for using this linker in PROTAC workflows are provided below.
Structure: The linker comprises an m-substituted polyethylene glycol chain terminated with a Boc-protected functionality. It contains ether linkages characteristic of PEG, along with a carbamate (Boc) motif that is stable under mild conditions but removable under acid. The overall structure is flexible, polar, and typically water-compatible.
Reactivity: Boc groups are commonly deprotected using mild to moderately acidic conditions to generate a free amine for subsequent coupling. For PROTAC assembly, the resulting amine can be used in amide-bond formation or related nucleophilic acyl substitution reactions with activated carboxylic acid derivatives. Suitable coupling strategies often employ standard peptide-coupling reagents in polar organic solvents, with temperature and stoichiometry adjusted to preserve sensitive warheads and ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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