Name: Mal-PEG4-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>95%

Solubility

Soluble in DCM, Water

Appearance

Pale Yellow Oily Liquid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Mal-PEG4-CH2CH2COOH; Maleimide-PEG4-CH2CH2COOH; Mal-PEG4-COOH; Mal-PEG4-propionic acid; 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oic acid; 15-maleinimido-4,7,10,13-tetroxapentadecanoic acid; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-

Boiling Point

520.1±50.0 °C at 760 mmHg

Density

1.268±0.06 g/cm3 (Predicted)

InChI Key

BTFZSOVKVDCKQD-UHFFFAOYSA-N

InChI

InChI=1S/C15H23NO8/c17-13-1-2-14(18)16(13)4-6-22-8-10-24-12-11-23-9-7-21-5-3-15(19)20/h1-2H,3-12H2,(H,19,20)

SMILES

C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCC(=O)O

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.8956 mL	14.4781 mL	28.9561 mL
5 mM	0.5791 mL	2.8956 mL	5.7912 mL
10 mM	0.2896 mL	1.4478 mL	2.8956 mL

Mal-PEG4-acid is a polyethylene glycol-based PROTAC linker bearing a maleimide functionality and a terminal carboxylic acid. It enables chemoselective conjugation to thiol-containing ligands while providing a hydrophilic spacer to tune solubility, reduce nonspecific interactions, and help position recruited binding motifs within PROTAC constructs. The maleimide handle supports robust assembly of targeted protein degraders, and the terminal acid provides a convenient functional group for further derivatization; detailed structural and reactivity considerations are provided below.

Structure: The linker comprises a maleimide electrophile connected to a short PEG chain terminating in a carboxylic acid. It contains an activated alkene within the maleimide ring and an ester-free ether-rich PEG segment. The presence of polar ether and acid groups supports water compatibility and flexible conformations.

Reactivity: Maleimides react selectively with thiols via Michael-type addition to form a stable thioether linkage, typically under mildly basic, aqueous-compatible conditions that preserve maleimide reactivity while controlling thiol oxidation. Assembly commonly uses thiol-bearing ligands or cysteine-reactive precursors. Solvent systems are chosen to balance solubility of PEG and reactants, and reaction progress is monitored to minimize hydrolysis or side reactions.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂