Fmoc-NH-PEG11-CH2CH2COOH
Cat No.: BP-502097
4.5 
Fmoc-NH-PEG11-CH2CH2COOH is a heterobifunctional PEG-based linker featuring an N-terminal Fmoc-protected amine for solid-phase or orthogonal coupling, a long, flexible hydrophilic polyethylene glycol chain that provides conformational freedom and reduces nonspecific interactions, and a terminal carboxylic acid for amide-bond formation or other carboxylate-reactive conjugation chemistries. In PROTAC and targeted protein degradation designs, such PEG linkers are commonly used to tune the spatial relationship between the ligand that recruits the target protein and the ligand that engages an E3 ubiquitin ligase, thereby influencing ternary complex formation, degradation potency, and cellular residence time. The extended ethylene glycol segment can also improve solubility and mitigate aggregation, which is particularly valuable for multicomponent conjugates. As a research-grade building block, it enables systematic linker-length and geometry optimization while maintaining compatibility with standard peptide/bioconjugation workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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This Fmoc-NH-PEG11-CH2CH2COOH linker is designed for modular synthesis of PROTACs, providing a chemically stable polyethylene glycol (PEG) spacer that can tune solubility and the effective reach between a ligand and an E3-recruiting moiety. Its orthogonally protected amine enables controlled coupling strategies, while the terminal carboxylic acid supports robust amide-bond formation. The subsequent points describe the linker’s structural features and practical use in PROTAC assembly.
Structure: The molecule combines an Fmoc-protected amine with a PEG-based oligomeric ether chain and a terminal ethyl–carboxylic acid functionality. It contains aromatic carbamate linkages (Fmoc), ether linkages along the PEG segment, and an aliphatic carboxylic acid for further conjugation.
Reactivity: PROTAC construction commonly uses the Fmoc group for stepwise synthesis, followed by deprotection under standard base conditions to reveal the free amine for coupling. The terminal carboxylic acid is then converted to an activated ester or coupled directly to an appropriately prepared amine-bearing partner using peptide-coupling reagents. Typical solvents include polar aprotic media, with reaction temperatures optimized to maintain PEG integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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