mPEG3-propyne
CAS No.: 89635-82-5
Cat No.: BP-500635
Purity: >98%
4.5 
mPEG3-propyne is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal propargyl (propyne) functionality, providing a short, flexible hydrophilic chain that can be used to modulate solubility and reduce nonspecific interactions in PROTAC-related constructs. Structurally, it combines a PEG segment with an alkyne handle suitable for bioorthogonal conjugation chemistries, most commonly copper-free azide–alkyne cycloaddition when paired with an azide-functional partner. In PROTAC design, this type of linker can serve as a spacer between the targeting ligand and the E3 ligase–recruiting module (or between other conjugation elements), helping to tune effective geometry and local concentration at the ternary-complex interface while maintaining favorable aqueous compatibility. Its value for targeted protein degradation research lies in enabling modular synthesis of degraders and facilitating late-stage attachment of functional groups under conditions compatible with sensitive biomolecule-derived ligands.
Structure of 89635-82-5
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mPEG3-propyne is an mPEG-based propargylated linker designed to support modular synthesis of PROTACs and related targeted degradation constructs. Its PEG-rich architecture provides solubility and flexible spacing between functional modules, while the terminal alkyne enables efficient chemoselective conjugation. These features make it useful for assembling degraders where controlled linkage geometry and reliable coupling chemistry are required.
Structure: The linker consists of a methoxy-terminated polyethylene glycol segment connected to a propargyl (terminal alkyne) group. It is characterized by ether linkages within the PEG chain and a carbon–carbon triple bond at the terminal alkyne, offering a stable, flexible, and hydrophilic scaffold.
Reactivity: The terminal alkyne supports standard click-type coupling strategies, most commonly copper(I)-catalyzed azide–alkyne cycloaddition for attaching azide-bearing ligands or handles used in PROTAC assembly. Reaction setups typically employ Cu(I) sources with appropriate stabilizing ligands, in polar organic or mixed solvent systems compatible with PEG solubility. Alternative alkyne-reactive conjugations can be selected when copper-free conditions are preferred.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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