Aminooxy-PEG3-methane
CAS No.: 248275-10-7
Cat No.: BP-500456
Purity: ≥95%
4.5 
Aminooxy-PEG3-methane is a methoxy-capped aminooxy PEG reagent. Structurally, it contains an aminooxy group attached to a PEG3 chain whose opposite terminus is a nonreactive methoxy group. The aminooxy handle reacts selectively with aldehydes or ketones to form oxime linkages under conditions chosen for the carbonyl partner, whereas the methoxy cap does not act as a methylene-based conjugation site. In PROTAC and related targeted protein degradation research, the molecule can install a short PEG–methoxy appendage on carbonyl-functionalized degrader intermediates or probes. Its defined architecture allows researchers to evaluate how linker polarity, flexibility, attachment sequence, and terminal-group selection influence conjugate preparation and the spatial requirements of productive target–E3 ligase engagement. Clear assignment of the protected and reactive groups also supports reproducible reaction planning and systematic comparison of alternative linker designs in research-focused targeted protein degradation workflows.
Structure of 248275-10-7
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Aminooxy-PEG3-methane is a PEG-based linker building block designed for modular assembly of PROTACs and related targeted protein degradation constructs. Its aminooxy functionality enables chemoselective conjugation strategies commonly used to connect ligands or reactive handles while maintaining favorable solubility and conformational flexibility. The PEG segment helps tune linker length and hydrophilicity, supporting efficient synthesis and compatibility with downstream biological evaluation. Detailed structural and reactivity considerations are provided below.
Structure: The molecule comprises an aminooxy group attached to a short PEG-derived chain terminated by a methane-derived scaffold. It contains ether linkages characteristic of polyethylene glycol motifs, along with an aminooxy functional group capable of forming oxime-type linkages. The overall structure is flexible and hydrophilic, supporting aqueous compatibility.
Reactivity: The aminooxy group is suited to oxime ligation chemistry with carbonyl-containing partners, typically under mildly acidic conditions to promote condensation while suppressing side reactions. Formation proceeds through nucleophilic addition to the carbonyl followed by dehydration to yield a stable oxime linkage. Commonly used solvents include aqueous buffers with compatible organic cosolvents, and no specialized catalysts are generally required beyond condition control.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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