Name: mPEG4-thiol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>95%

Appearance

Colorless Liquid

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanethiol

Synonyms

2,5,8,11-Tetraoxatridecane-13-thiol

Boiling Point

293.5±30.0 °C at 760 mmHg

InChI Key

VXEBAWYHFQRROQ-UHFFFAOYSA-N

InChI

InChI=1S/C9H20O4S/c1-10-2-3-11-4-5-12-6-7-13-8-9-14/h14H,2-9H2,1H3

SMILES

COCCOCCOCCOCCS

mPEG4-thiol is a methoxy PEG thiol linker that combines hydrophilic PEG spacing with thiol-directed conjugation chemistry. It is suitable for PROTAC designs requiring thioether connectivity and improved polar character without introducing a long spacer. The molecule is described below.

Structure: The linker contains a methoxy-terminated PEG chain and a terminal thiol group. It features flexible ether bonds, a polar nonionic backbone, and a sulfur nucleophile for selective coupling.

Reactivity: The thiol can undergo Michael addition with maleimide-functional fragments or nucleophilic substitution with activated haloalkyl partners. Reactions are commonly conducted under mild, non-oxidizing conditions in polar organic or aqueous-organic solvents. Fresh thiol solutions, compatible base, and minimized competing electrophiles support clean PROTAC intermediate formation.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂