Name: Ms-PEG6-THP
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl methanesulfonate

InChI Key

PCSQWQKEAAOPKF-UHFFFAOYSA-N

InChI

InChI=1S/C18H36O10S/c1-29(19,20)28-17-15-25-13-11-23-9-7-21-6-8-22-10-12-24-14-16-27-18-4-2-3-5-26-18/h18H,2-17H2,1H3

SMILES

CS(=O)(=O)OCCOCCOCCOCCOCCOCCOC1CCCCO1

This differentially protected oligoether linker precursor combines a mesylate electrophile with a masked alcohol. It supports nucleophilic installation of a ligand-facing group followed by selective alcohol unveiling, offering a flexible route to unsymmetrical PROTAC linker construction. Detailed characteristics are provided below.

Structure: A linear oligoether chain is capped by a methanesulfonate and a tetrahydropyranyl-protected alcohol. The structure contains flexible ether bonds, a sulfonate ester with an effective leaving group, and an acid-labile cyclic acetal that masks the opposing hydroxyl terminus.

Reactivity: The mesylate undergoes bimolecular nucleophilic substitution with amines, thiolates, phenoxides, or azide in a polar aprotic solvent such as dimethylformamide or acetonitrile, using a suitable base when nucleophile generation is required. Mild aqueous acid removes the tetrahydropyranyl group to reveal an alcohol, which can then be converted into an ester, carbonate, carbamate, or another activated linker handle.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂