Name: N-(3-Aminopropyl)biotinamide trifluoroacetate
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>98%

Storage

Store at 2-8 °C

IUPACName

5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(3-aminopropyl)pentanamide;2,2,2-trifluoroacetic acid

Synonyms

N-(+)-Biotinyl-3-aminopropylammonium trifluoroacetate; Biotinyl-DAPr.TFA; N-(3-Aminopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide 2,2,2-trifluoroacetate; 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(3-aminopropyl)hexahydro-2-oxo-, (3aS,4S,6aR)-, 2,2,2-trifluoroacetate (1:1); 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(3-aminopropyl)hexahydro-2-oxo-, (3aS,4S,6aR)-, mono(trifluoroacetate)

InChI Key

XIFKYHZIURRTHB-SVMJMOIZSA-N

InChI

InChI=1S/C13H24N4O2S.C2HF3O2/c14-6-3-7-15-11(18)5-2-1-4-10-12-9(8-20-10)16-13(19)17-12;3-2(4,5)1(6)7/h9-10,12H,1-8,14H2,(H,15,18)(H2,16,17,19);(H,6,7)/t9-,10-,12-;/m0./s1

SMILES

C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NCCCN)NC(=O)N2.C(=O)(C(F)(F)F)O

This biotin-based PROTAC linker reagent enables modular assembly of targeted protein degraders by providing a biotin-derived recognition handle alongside a primary amine for controlled conjugation chemistry. Its trifluoroacetate counterion supports convenient handling and salt formation, facilitating coupling strategies commonly used to connect ligands, linkers, and E3-recruiting motifs. The structural and reactivity features described below will be detailed to support experimental design and PROTAC construction.

Structure: The linker comprises a biotinamide framework bearing an N-(3-aminopropyl) substituent, with an amide linkage and a terminal primary amine. The trifluoroacetate forms an ionic salt with the amine, improving stability and solubility. The molecule contains heteroatoms suited for hydrogen bonding and bioconjugation.

Reactivity: The primary amine enables standard PROTAC linker formation via nucleophilic substitution or amide/urea coupling with activated carboxylic acids, NHS-esters, or isocyanates, typically under mild base conditions. The trifluoroacetate counterion can be removed or neutralized in situ to free the amine for coupling. Common solvents include polar aprotic media, and reactions are often conducted at controlled temperature to preserve sensitive functional groups and maintain coupling efficiency.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂