t-Boc-N-amido-PEG7-propionic acid
CAS No.: 2055044-68-1
Cat No.: BP-501314
Purity: ≥95%
4.5 
t-Boc-N-amido-PEG7-propionic acid is a PEG-based PROTAC linker building block featuring a terminal Boc-protected amine (carbamate) and a carboxylic acid handle. The PEG7 segment provides a hydrophilic, flexible spacer that can reduce steric interference and improve solubility of conjugates, while the propionic acid functionality serves as a reactive anchor for amide or ester bond formation to connect either the E3 ligase ligand or the target-binding moiety. In PROTAC design, such linkers help position the two binding elements at an appropriate distance and orientation to promote formation of the ternary complex and subsequent ubiquitination-driven degradation. As a modular intermediate, it is valuable for assembling and optimizing targeted protein degradation constructs, allowing researchers to systematically tune linker length, polarity, and conjugation strategy during structure–activity relationship studies.
Structure of 2055044-68-1
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t-Boc-N-amido-PEG7-propionic acid is a PEG-based PROTAC linker building block designed to provide a flexible, hydrophilic spacer that can improve solubility and support productive ternary complex formation. Its protected amide functionality enables controlled conjugation to targeting ligands and subsequent assembly of degraders under standard synthetic workflows. The following sections describe the linker’s structural features and practical reactivity considerations for PROTAC construction.
Structure: The linker contains a polyethylene glycol chain that confers conformational flexibility and water-compatible polarity, connected through an amide linkage to a propionic acid functionality. A t-Boc-protecting group on the nitrogen supports selective deprotection and downstream coupling chemistry.
Reactivity: PROTAC synthesis commonly uses t-Boc deprotection under acidic conditions to reveal the amine for amide or carbamate-forming coupling. The carboxylic acid can be activated via standard carboxyl activation strategies (e.g., coupling reagents) to react with amine-bearing ligands. Reaction design should prioritize mild conditions compatible with sensitive functional groups and maintain linker solubility in polar solvents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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