N-(Mal-PEG6)-N-bis(PEG7-TCO)
CAS No.: 2093152-84-0
Cat No.: BP-500947
4.5 
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a bifunctional PROTAC linker designed to connect a maleimide-terminated PEG segment to two TCO (trans-cyclooctene) groups via PEG7 spacers. Structurally, it comprises a central tertiary amide nitrogen substituted with one maleimide-bearing PEG6 chain and two PEG7-TCO arms, providing a flexible, hydrophilic scaffold that reduces steric constraints and improves effective reach between conjugated partners. In targeted protein degradation workflows, the maleimide moiety enables selective coupling to thiol-containing ligands or cysteine residues on a binding module, while the TCO groups serve as strained-alkene handles for subsequent bioorthogonal ligation to tetrazine-functionalized components. The dual TCO architecture can increase the probability of productive ternary complex formation by allowing multivalent engagement or improved spatial organization. This linker is valuable for assembling modular PROTACs and related degradation constructs where controlled conjugation, tunable distance, and aqueous solubility are critical for reliable synthesis and downstream biochemical evaluation.
Structure of 2093152-84-0
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a multifunctional PROTAC linker designed to integrate a maleimide handle with two TCO moieties through PEG-based spacers. Its flexible, hydrophilic architecture supports efficient conjugation and favorable spatial presentation of reactive groups, while the TCO units enable rapid, bioorthogonal engagement with tetrazines in targeted protein degradation workflows. The
Structure: The linker comprises a maleimide-derived electrophilic group and two trans-cyclooctene (TCO) units connected via long polyethylene glycol (PEG) chains. It contains carbonyl and olefinic functionalities, with ether linkages in the PEG segments. Overall, it is a flexible, water-compatible scaffold suitable for bioconjugation.
Reactivity: The maleimide functionality is typically used for selective thiol–maleimide coupling under mildly basic aqueous conditions, forming stable thioether linkages. The TCO groups participate in fast inverse-electron-demand Diels–Alder reactions with tetrazines, enabling efficient click-style assembly of PROTAC constructs. Conjugation is commonly performed in buffered aqueous media, with careful control of pH, thiol availability, and TCO stability to preserve reactivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
