N-(Azido-PEG3)-N-Boc-PEG4-acid
CAS No.: 2112731-95-8
Cat No.: BP-500219
Purity: 98%
4.5 
N-(Azido-PEG3)-N-Boc-PEG4-acid is a multifunctional, N-protected branched PEG linker. Structurally, it contains an N-Boc-protected nitrogen joining an azido-PEG3 segment to a PEG4 chain terminated with a free propionic acid. The carboxylic acid can be activated for amide coupling, the azide enables CuAAC or SPAAC, and N-Boc removal reveals a secondary amine for an additional functionalization step. In PROTAC and related targeted protein degradation research, these distinct reactive elements permit staged conjugation of ligands, probes, or auxiliary groups without describing the free acid as a protected carboxylate. Its defined architecture allows researchers to evaluate how linker polarity, flexibility, attachment sequence, and terminal-group selection influence conjugate preparation and the spatial requirements of productive target–E3 ligase engagement. Clear assignment of the protected and reactive groups also supports reproducible reaction planning and systematic comparison of alternative linker designs in research-focused targeted protein degradation workflows.
Structure of 2112731-95-8
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N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker building block designed to provide aqueous compatibility, conformational flexibility, and a chemically addressable azide handle for modular assembly. The Boc-protected amine and terminal acid functionality enable controlled coupling strategies that support reliable synthesis of targeted protein degraders. Its use in PROTAC workflows facilitates efficient conjugation of ligands while maintaining linker solubility and minimizing steric constraints; detailed structural and reactivity considerations follow below.
Structure: The molecule comprises polyethylene glycol segments connected through ether linkages, incorporating a terminal carboxylic acid and a Boc-protected nitrogen. An azide substituent provides a stable, bioorthogonal functional group for click-type conjugation, while the PEG chains impart hydrophilicity and conformational mobility.
Reactivity: The azide group is suited for copper-catalyzed azide–alkyne cycloaddition or related azide click chemistries under standard inert conditions, typically using Cu(I)-generating systems and appropriate ligands to control reactivity. The Boc group can be removed under mild acid conditions to reveal an amine for amide or carbamate-forming couplings with activated carboxylic acid derivatives. The terminal acid supports standard coupling chemistries using common activating reagents and bases in polar solvents.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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