Propargyl-PEG2-Ms
CAS No.: 943726-01-0
Cat No.: BP-500867
Purity: 98%
4.5 
Propargyl-PEG2-Ms is a bifunctional polyethylene glycol linker bearing a terminal propargyl group and a mesylate (Ms) leaving group. Structurally, it combines a short PEG spacer that provides aqueous solubility and conformational flexibility with two orthogonal reactive handles: the propargyl moiety enables copper-catalyzed azide–alkyne cycloaddition (CuAAC) or other alkyne-based conjugations, while the mesylate can be displaced by nucleophiles such as amines or thiols to form stable C–N or C–S linkages. In PROTAC construction, this type of linker is used to connect a ligand-bearing nucleophile to the PEG spacer, then to install a second functional group for subsequent coupling to the complementary recruitment ligand or reporter tag. The short PEG length helps maintain productive geometry for ternary complex formation while improving handling and reducing nonspecific aggregation. Overall, Propargyl-PEG2-Ms is a practical building block for modular, stepwise synthesis of targeted protein degraders and related conjugates.
Structure of 943726-01-0
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Propargyl-PEG2-Ms is a polyethylene glycol-based PROTAC linker designed to connect targeting ligands through a chemically versatile leaving group. Its PEG segment provides aqueous compatibility and conformational flexibility, while the propargyl handle enables efficient conjugation strategies commonly used in targeted protein degradation workflows. This product supports the stepwise assembly of bifunctional degraders, and the following points describe its structure and practical reactivity for PROTAC construction in detail below.
Structure: The linker contains a PEG spacer that introduces ether-rich, flexible segments, coupled to a propargyl functionality and a mesylate-derived leaving group. It features alkyne and ether linkages, with an overall polar, hydrophilic character that promotes solubility in common PROTAC synthesis solvents.
Reactivity: The mesylate moiety is suitable for nucleophilic substitution, enabling replacement by amines or other nucleophiles under mild, base-assisted conditions. The propargyl group can participate in copper-catalyzed azide–alkyne cycloaddition or related alkyne coupling approaches, allowing orthogonal attachment to partner fragments. Typical coupling uses inert atmosphere control, appropriate bases, and compatible solvents to preserve sensitive ligands during assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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