Propargyl-PEG7-acid
CAS No.: 2093154-00-6
Cat No.: BP-500560
Purity: >95%
4.5 
Propargyl-PEG7-acid is a polyethylene glycol (PEG) linker bearing a terminal propargyl (alkyne) handle and a carboxylic acid for conjugation. Structurally, it provides a flexible, hydrophilic PEG chain of intermediate length that can spatially separate a PROTAC warhead from an E3 ligase–binding ligand, helping to reduce steric clashes and improve productive ternary complex formation. The propargyl group enables chemoselective “click” reactions (typically Cu(I)-catalyzed azide–alkyne cycloaddition) to attach the linker to azide-functional partners, while the carboxylic acid offers a reactive site for amide coupling or other carboxyl-derivatization strategies. In targeted protein degradation research, this bifunctional linker is valuable for modular PROTAC synthesis, allowing researchers to systematically tune linker length and attachment geometry to optimize degradation potency, selectivity, and physicochemical properties for in vitro studies.
Structure of 2093154-00-6
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Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based PROTAC linker featuring a terminal alkyne (propargyl) for bioorthogonal conjugation and a carboxylic acid handle for controlled attachment to ligands. Its flexible PEG segment can improve solubility and spatial reach, supporting efficient formation of ternary complexes in targeted protein degradation workflows. The following points describe the linker’s structure and the practical reactivity considerations for PROTAC assembly in detail below.
Structure: The linker contains a PEG chain that provides conformational flexibility, terminated by a propargyl group and a terminal carboxylic acid. It includes ether linkages within the PEG backbone, an alkyne for selective coupling, and a carboxylic acid for amide or ester formation, supporting robust, modular synthesis.
Reactivity: The terminal alkyne enables click-type conjugation strategies (e.g., copper-catalyzed azide–alkyne cycloaddition) under conditions commonly used for PROTAC linker installation, typically employing suitable copper catalysts and appropriate solvents while minimizing side reactions. The carboxylic acid can be activated for amide bond formation with amine-bearing ligands using standard coupling chemistries. Together, these functionalities support stepwise, modular PROTAC construction via well-established coupling and bioorthogonal principles.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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