Semaglutide Impurity 7
CAS No.: 843666-34-2
Cat No.: BP-501330
4.5 
Semaglutide Impurity 7 (CAS 843666-34-2) is a small-molecule lipid-chain building block rather than a full semaglutide peptide impurity. Structurally, it is 1-O-tert-butyl 18-O-(2,5-dioxopyrrolidin-1-yl) octadecanedioate, containing a long C16 spacer between a tert-butyl ester-protected carboxylic acid and an amine-reactive N-hydroxysuccinimide (NHS) ester. The NHS ester can be coupled to primary amines to form an amide bond, while the tert-butyl ester can be removed to reveal the second carboxylic acid for further functionalization. Accordingly, this material is better described as a protected long-chain diacid/NHS-ester building block that can support stepwise conjugation workflows, rather than as a structurally altered semaglutide peptide used only for analytical impurity profiling.
Structure of 843666-34-2
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* For research and manufacturing use only. Not for human or clinical use.
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Despite the product label, the supplied structure fields correspond to a long-chain dicarboxylic acid derivative bearing one tert-butyl ester and one N-hydroxysuccinimide (NHS) ester. As represented by the supplied structure, this material behaves as an activated long-chain acylating building block rather than a peptide or GLP-1 analog. The points below describe the molecule’s structure-related features and practical considerations for reactivity in PROTAC assembly.
Structure: The supplied structure is an aliphatic C18 dicarboxylic acid derivative with one carboxyl group protected as a tert-butyl ester and the other activated as an NHS ester. Its covalent connectivity is dominated by a long hydrocarbon chain and terminal ester functionalities, with no peptide sequence or amide-rich framework.
Reactivity: The NHS ester can react with primary amines by nucleophilic acyl substitution to form an amide linkage, while the tert-butyl ester protects the second carboxylic acid. The NHS-ester coupling is commonly performed under mild amine-reactive conditions, and the tert-butyl ester can be removed separately under acidic conditions when the second carboxylic acid is required. Reaction monitoring by LC–MS is recommended to confirm completion and minimize side products.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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