Br-PEG3-CH2COOH
CAS No.: 1346502-15-5
Cat No.: BP-501316
Purity: ≥95%
4.5 
Br-PEG3-CH2COOH is a bromine-terminated, short-chain polyethylene glycol (PEG) linker bearing a terminal carboxymethyl group, providing a flexible hydrophilic spacer with two orthogonal functional handles for PROTAC assembly. The PEG segment improves aqueous solubility and can reduce steric interference between the “warhead” ligand and the E3-recruiting moiety, while the terminal bromide enables selective coupling to nucleophilic partners (for example, via substitution or controlled conjugation chemistries). The carboxylic acid can be used for amide-bond formation, enabling attachment to targeting ligands or to linker junctions that position the degradative complex for productive ternary assembly. In targeted protein degradation research, such PEG linkers are widely used to tune linker length, flexibility, and polarity, thereby optimizing degradation potency and selectivity across different PROTAC architectures. This reagent is therefore valuable for systematic linker screening and for constructing reproducible, modular conjugates for mechanistic studies of induced proximity.
Structure of 1346502-15-5
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Br-PEG3-CH2COOH is a bromo-terminated, poly(ethylene glycol) linker bearing a terminal carboxylic acid, designed for modular assembly of PROTACs and related targeted protein degradation constructs. Its PEG-based segment supports solubility and conformational flexibility, while the bromo handle enables chemoselective functionalization. The carboxyl group provides a convenient site for coupling to ligand scaffolds, facilitating streamlined synthesis and optimization of degradation agents; detailed structural and reactivity considerations are provided below.
Structure: The linker combines a terminal bromomethyl group with a short PEG chain and a terminal carboxylic acid. It contains ether linkages within the PEG segment, a carbon–bromine bond at the terminus, and a carboxylic acid functionality capable of hydrogen bonding and ionic interactions, supporting improved aqueous compatibility.
Reactivity: The bromo terminus is suitable for nucleophilic substitution or related alkylation strategies to install PROTAC attachment motifs, typically under conditions that minimize side reactions such as elimination. The carboxylic acid can be activated for amide or ester bond formation using standard coupling chemistries, often employing activating reagents and base in polar organic solvents, enabling efficient conjugation to targeting ligands while preserving linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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