mPEG5-bromide
CAS No.: 854601-80-2
Cat No.: BP-500516
Purity: >95%
4.5 
mPEG5-bromide is a monofunctional methoxy-poly(ethylene glycol) bromide reagent featuring a short, defined PEG chain terminated with a reactive bromide. Structurally, it provides a hydrophilic, flexible spacer that can be used to introduce PEGylation-like properties while retaining a handle for subsequent chemical transformation. In PROTAC and targeted protein degradation workflows, such PEG linkers are commonly employed to tune solubility, reduce nonspecific hydrophobic interactions, and modulate the effective distance and orientation between a ligand-bearing “warhead” and the E3-recruiting module. The terminal bromide enables conversion into more stable or orthogonally reactive intermediates (e.g., for nucleophilic substitution or further functionalization), facilitating controlled conjugation strategies during linker assembly. As a practical building block, mPEG5-bromide supports iterative linker optimization, helping researchers improve physicochemical behavior and experimental handling of degraders without introducing additional bulky degradable motifs.
Structure of 854601-80-2
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
mPEG5-bromide is an mPEG-based brominated linker reagent designed to enable ether-linked conjugation steps commonly used in PROTAC synthesis workflows. Its PEG character supports solubility and improved handling of conjugates, while the bromide functionality provides a versatile electrophilic handle for downstream coupling. The following points describe the linker’s structure and practical reactivity considerations in detail.
Structure: mPEG5-bromide consists of a methoxy-terminated polyethylene glycol chain bearing a terminal bromide. The molecule features repeating ether linkages along the PEG backbone and a carbon–bromine bond at the reactive terminus. Its flexible, hydrophilic PEG architecture typically confers good water compatibility and reduced aggregation.
Reactivity: The terminal bromide can participate in nucleophilic substitution reactions to form C–O or C–N bonds when paired with appropriate nucleophiles used to build PROTAC conjugates. Suitable conditions generally involve polar aprotic solvents, controlled temperature, and base selection compatible with both the nucleophile and the functional groups on the partner ligand. Reaction pathways follow standard SN-type substitution principles, with careful consideration of nucleophile strength and steric accessibility.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
