VH-298

 CAS No.: 2097381-85-4  Cat No.: BP-200030  Purity: ≥98% by HPLC 4.5  

VH-298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd value of 80-90 nM) that could block VHL and HIF-α interactions. VH-298 can be used in PROTAC technology.

VH-298

Structure of 2097381-85-4

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Ligand for E3 Ligase
Molecular Formula
C₂₇H₃₃N₅O₄S
Molecular Weight
523.65

* For research and manufacturing use only. Not for human or clinical use.

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50 mg $469 In stock

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Purity
≥98% by HPLC
Solubility
DMSO: ≥ 83.3 mg/mL (159.08 mM)
Application
Enzyme Inhibitors
Storage
Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Synonyms
(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; EX-A1505; VH 298; VH298; VH-298
InChI Key
NDVQUNZCNAMROD-RZUBCFFCSA-N
InChI
InChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
Canonical SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O
Pub Chem ID
122199236
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM1.91 mL9.55 mL19.1 mL
5 mM0.38 mL1.91 mL3.82 mL
10 mM0.19 mL0.95 mL1.91 mL
50 mM0.04 mL0.19 mL0.38 mL

Hello, can I ask if VH-298 has any enzyme inhibitory effect?

Yes. As an enzyme inhibitor, VH-298 prevents normal substrate-enzyme binding and catalytic reactions.

28/1/2021

Hi! Do you have any information on the solubility of VH-298?

Dear Sir, Our database shows that the solubility of VH-298 in DMSO is greater than 83.3 mg/mL.

3/1/2022

PROTAC development

In our project, we use VH-298 to develop PROTAC technology. It works great!

29/4/2017

enzyme inhibitor

As expected! VH-298 showed excellent enzyme inhibitory effect in our study.

8/2/2022

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: Ac4GlcNAlk | 2,2'-(Ethylenedioxy)bis(ethylamine) | Biotin-BS | cIAP1 Ligand-Linker Conjugates 15 | Pomalidomide-C2-NH2 (hydrochloride) | Methyl acetate-PEG1-methyl acetate | ARV-771 | TD-106 | Pomalidomide-PEG2-azide | SLF-amido-C2-COOH | VH-298

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