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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-(2-(2-(4-(3-((4-((4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)sulfonyl)propyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione BPL-202313 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-(2-(2-(4-(3-((4-((4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)sulfonyl)propyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione 2765641-93-6

CRBN

CDK2

 Inquiry

Molecular Weight: 898.02

Molecular Formula: C43H51N11O9S

Density: 1.45±0.1 g/cm3

Description: It is a selective CDK2 degrader that protects against cisplatin-and noise-induced hearing loss.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-(3-((4-((4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)sulfonyl)propyl)-1H-1,2,3-triazol-1-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202314 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-(3-((4-((4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)sulfonyl)propyl)-1H-1,2,3-triazol-1-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2765641-87-8

VHL

CDK2

 Inquiry

Molecular Weight: 981.22

Molecular Formula: C48H60N12O7S2

Density: 1.38±0.1 g/cm3

Description: It is a selective CDK2 degrader that protects against cisplatin-and noise-induced hearing loss.
4-[(2,6-Difluorobenzoyl)amino]-N-[trans-4-[[1-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]cyclohexyl]-1H-pyrazole-3-carboxamide BPL-202315 4-[(2,6-Difluorobenzoyl)amino]-N-[trans-4-[[1-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]cyclohexyl]-1H-pyrazole-3-carboxamide 2765641-97-0

CRBN

CDK2

 Inquiry

Molecular Weight: 876.88

Molecular Formula: C41H46F2N10O10

Density: 1.55±0.1 g/cm3

Description: It is a selective CDK2 degrader that protects against cisplatin-and noise-induced hearing loss.
4-(2,6-Difluorobenzamido)-N-(4-((1-(2-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)cyclohexyl)-1H-pyrazole-3-carboxamide BPL-202316 4-(2,6-Difluorobenzamido)-N-(4-((1-(2-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)cyclohexyl)-1H-pyrazole-3-carboxamide 2765641-95-8

VHL

CDK2

 Inquiry

Molecular Weight: 960.08

Molecular Formula: C46H55F2N11O8S

Density: 1.47±0.1 g/cm3

Description: It is a selective CDK2 degrader that protects against cisplatin-and noise-induced hearing loss.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)piperidin-4-yl)-3-methoxybenzamide BPL-202317 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)piperidin-4-yl)-3-methoxybenzamide 2869057-02-1

CRBN

BRD4

 Inquiry

Molecular Weight: 902.07

Molecular Formula: C48H59N11O7

Density: 1.45±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)piperidin-4-yl)-3-methoxybenzamide BPL-202318 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)piperidin-4-yl)-3-methoxybenzamide 2869057-03-2

CRBN

BRD4

 Inquiry

Molecular Weight: 916.08

Molecular Formula: C49H61N11O7

Density: 1.44±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
WWL0202 BPL-202319 WWL0202 2869057-04-3

CRBN

BRD4

 Inquiry

Molecular Weight: 930.12

Molecular Formula: C50H63N11O7

Density: 1.42±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)piperidin-4-yl)-3-methoxybenzamide BPL-202320 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)piperidin-4-yl)-3-methoxybenzamide 2869057-05-4

CRBN

BRD4

 Inquiry

Molecular Weight: 944.15

Molecular Formula: C51H65N11O7

Density: 1.41±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonyl)piperidin-4-yl)-3-methoxybenzamide BPL-202321 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonyl)piperidin-4-yl)-3-methoxybenzamide 2869057-07-6

CRBN

BRD4

 Inquiry

Molecular Weight: 958.18

Molecular Formula: C52H67N11O7

Density: 1.40±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(10-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)decyl)piperidin-4-yl)-3-methoxybenzamide BPL-202322 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(10-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)decyl)piperidin-4-yl)-3-methoxybenzamide 2869057-08-7

CRBN

BRD4

 Inquiry

Molecular Weight: 972.21

Molecular Formula: C53H69N11O7

Density: 1.39±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)undecyl)piperidin-4-yl)-3-methoxybenzamide BPL-202323 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)undecyl)piperidin-4-yl)-3-methoxybenzamide 2869057-09-8

CRBN

BRD4

 Inquiry

Molecular Weight: 986.23

Molecular Formula: C54H71N11O7

Density: 1.38±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)piperidin-4-yl)-3-methoxybenzamide BPL-202324 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)piperidin-4-yl)-3-methoxybenzamide 2869057-10-1

CRBN

BRD4

 Inquiry

Molecular Weight: 945.10

Molecular Formula: C49H60N12O8

Density: 1.48±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
WWL0245 BPL-202325 WWL0245 2869057-11-2

CRBN

BRD4

 Inquiry

Molecular Weight: 873.97

Molecular Formula: C45H51N11O8

Density: 1.53±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)butanoyl)piperidin-4-yl)-3-methoxybenzamide BPL-202326 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)butanoyl)piperidin-4-yl)-3-methoxybenzamide 2869057-12-3

CRBN

BRD4

 Inquiry

Molecular Weight: 902.03

Molecular Formula: C47H55N11O8

Density: 1.50±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentanoyl)piperidin-4-yl)-3-methoxybenzamide BPL-202327 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentanoyl)piperidin-4-yl)-3-methoxybenzamide 2869057-13-4

CRBN

BRD4

 Inquiry

Molecular Weight: 916.05

Molecular Formula: C48H57N11O8

Density: 1.48±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoyl)piperidin-4-yl)-3-methoxybenzamide BPL-202328 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoyl)piperidin-4-yl)-3-methoxybenzamide 2869057-14-5

CRBN

BRD4

 Inquiry

Molecular Weight: 930.08

Molecular Formula: C49H59N11O8

Density: 1.47±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptanoyl)piperidin-4-yl)-3-methoxybenzamide BPL-202329 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptanoyl)piperidin-4-yl)-3-methoxybenzamide 2869057-15-6

CRBN

BRD4

 Inquiry

Molecular Weight: 944.11

Molecular Formula: C50H61N11O8

Density: 1.45±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)glycyl)piperidin-4-yl)-3-methoxybenzamide BPL-202330 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)glycyl)piperidin-4-yl)-3-methoxybenzamide 2869057-16-7

CRBN

BRD4

 Inquiry

Molecular Weight: 859.01

Molecular Formula: C45H54N12O6

Density: 1.51±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)pentanoyl)piperidin-4-yl)-3-methoxybenzamide BPL-202331 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)pentanoyl)piperidin-4-yl)-3-methoxybenzamide 2869057-17-8

CRBN

BRD4

 Inquiry

Molecular Weight: 901.09

Molecular Formula: C48H60N12O6

Density: 1.46±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexanoyl)piperidin-4-yl)-3-methoxybenzamide BPL-202332 4-(((R)-5-(Cyclohexylmethyl)-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridin-7-yl)amino)-N-(1-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexanoyl)piperidin-4-yl)-3-methoxybenzamide 2869057-18-9

CRBN

BRD4

 Inquiry

Molecular Weight: 915.11

Molecular Formula: C49H62N12O6

Density: 1.44±0.1 g/cm3

Description: It is a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.

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