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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
N-(35-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202673 N-(35-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267291-00-7

CRBN

Tau

 Inquiry

Molecular Weight: 1023.15

Molecular Formula: C51H70N6O16

Boiling Point: 1096.9±65.0°C at 760 Torr

Density: 1.284±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
N-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202674 N-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267290-93-5

CRBN

Tau

 Inquiry

Molecular Weight: 594.67

Molecular Formula: C33H34N6O5

Boiling Point: 963.9±65.0°C at 760 Torr

Density: 1.384±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
N-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202675 N-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267291-14-3

CRBN

Tau

 Inquiry

Molecular Weight: 627.65

Molecular Formula: C33H33N5O8

Boiling Point: 954.5±65.0°C at 760 Torr

Density: 1.404±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
N-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202676 N-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267291-16-5

CRBN

Tau

 Inquiry

Molecular Weight: 671.71

Molecular Formula: C35H37N5O9

Boiling Point: 964.8±65.0°C at 760 Torr

Density: 1.381±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
N-(14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12-tetraoxatetradecyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202677 N-(14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12-tetraoxatetradecyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267291-17-6

CRBN

Tau

 Inquiry

Molecular Weight: 715.76

Molecular Formula: C37H41N5O10

Boiling Point: 976.7±65.0°C at 760 Torr

Density: 1.361±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
N-(5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202678 N-(5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267291-18-7

CRBN

Tau

 Inquiry

Molecular Weight: 581.63

Molecular Formula: C32H31N5O6

Boiling Point: 939.2±65.0°C at 760 Torr

Density: 1.392±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
N-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202679 N-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267291-15-4

CRBN

Tau

 Inquiry

Molecular Weight: 595.66

Molecular Formula: C33H33N5O6

Boiling Point: 939.8±65.0°C at 760 Torr

Density: 1.371±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
(2S,4R)-1-((S)-2-(tert-Butyl)-4,14-dioxo-16-(5H-pyrido[4,3-b]indol-7-yl)-7,10-dioxa-3,13-diazahexadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202680 (2S,4R)-1-((S)-2-(tert-Butyl)-4,14-dioxo-16-(5H-pyrido[4,3-b]indol-7-yl)-7,10-dioxa-3,13-diazahexadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2267291-01-8

VHL

Tau

 Inquiry

Molecular Weight: 826.03

Molecular Formula: C44H55N7O7S

Boiling Point: 1116.6±65.0°C at 760 Torr

Density: 1.276±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
(2S,4R)-1-((S)-2-(tert-Butyl)-4,20-dioxo-22-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13,16-tetraoxa-3,19-diazadocosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202681 (2S,4R)-1-((S)-2-(tert-Butyl)-4,20-dioxo-22-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13,16-tetraoxa-3,19-diazadocosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2267291-03-0

VHL

Tau

 Inquiry

Molecular Weight: 914.14

Molecular Formula: C48H63N7O9S

Boiling Point: 1149.9±65.0°C at 760 Torr

Density: 1.259±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
(2S,4R)-1-((S)-2-(tert-Butyl)-4,26-dioxo-28-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13,16,19,22-hexaoxa-3,25-diazaoctacosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202682 (2S,4R)-1-((S)-2-(tert-Butyl)-4,26-dioxo-28-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13,16,19,22-hexaoxa-3,25-diazaoctacosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2267291-04-1

VHL

Tau

 Inquiry

Molecular Weight: 1002.24

Molecular Formula: C52H71N7O11S

Boiling Point: 1177.3±65.0°C at 760 Torr

Density: 1.245±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
(2S,4R)-1-((S)-2-(8-(3-(5H-Pyrido[4,3-b]indol-7-yl)propanamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202683 (2S,4R)-1-((S)-2-(8-(3-(5H-Pyrido[4,3-b]indol-7-yl)propanamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2267291-05-2

VHL

Tau

 Inquiry

Molecular Weight: 808.06

Molecular Formula: C45H57N7O5S

Boiling Point: 1098.3±65.0°C at 760 Torr

Density: 1.241±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.
PPC5 BPL-202684 PPC5 2471969-10-3

VHL

BCL-xL
BCL2

 Inquiry

Molecular Weight: 1599.44

Molecular Formula: C79H99ClF3N11O11S4

Density: 1.41±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
PPC6 BPL-202685 PPC6 2471969-13-6

VHL

BCL-xL
BCL2

 Inquiry

Molecular Weight: 1613.47

Molecular Formula: C80H101ClF3N11O11S4

Density: 1.40±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
PPC7 BPL-202686 PPC7 2471969-14-7

VHL

BCL2
BCL-xL

 Inquiry

Molecular Weight: 1627.47

Molecular Formula: C81H103ClF3N11O11S4

Density: 1.39±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
PPC8 BPL-202687 PPC8 2471969-16-9

VHL

BCL2
BCL-xL

 Inquiry

Molecular Weight: 1641.52

Molecular Formula: C82H105ClF3N11O11S4

Density: 1.39±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
PPC9 BPL-202688 PPC9 2471969-19-2

VHL

BCL2
BCL-xL

 Inquiry

Molecular Weight: 1655.55

Molecular Formula: C83H107ClF3N11O11S4

Density: 1.38±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
PPC10 BPL-202689 PPC10 2471969-22-7

VHL

BCL2
BCL-xL

 Inquiry

Molecular Weight: 1669.58

Molecular Formula: C84H109ClF3N11O11S4

Density: 1.37±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
PPC11 BPL-202690 PPC11 2471969-24-9

VHL

BCL2
BCL-xL

 Inquiry

Molecular Weight: 1683.59

Molecular Formula: C85H111ClF3N11O11S4

Density: 1.37±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
753a BPL-202691 753a 2471970-59-7

VHL

BCL2
BCL-xL

 Inquiry

Molecular Weight: 1641.52

Molecular Formula: C82H105ClF3N11O11S4

Density: 1.39±0.1 g/cm3

Description: It is a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
N1-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N7-hydroxyheptanediamide BPL-202692 N1-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N7-hydroxyheptanediamide 2758388-35-9

CRBN

HDAC1
HDAC3
HDAC6

 Inquiry

Molecular Weight: 416.43

Molecular Formula: C20H24N4O6

Density: 1.415±0.06 g/cm3

Description: It is an HDAC degrader with a CRBN E3 ligase ligand.

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