PROTAC Library

Loading...
E3 Ligase
Target
Molecular Weight
to
Your selection
  • Your selection
Structure Catalog Product Name CAS E3 Ligase Target Inquiry
(7S)-7-(1-(3-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide BPL-202573 (7S)-7-(1-(3-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2599845-25-5

CRBN

BTK

 Inquiry

Molecular Weight: 870.97

Molecular Formula: C46H50N10O8

Density: 1.52±0.1 g/cm3

Description: It is a PROTAC that mediates the degradation of Bruton's tyrosine kinase as a therapeutic strategy for cancer.
(7S)-7-(1-(3-(((1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)(methyl)amino)propanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide BPL-202574 (7S)-7-(1-(3-(((1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)(methyl)amino)propanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2599845-26-6

CRBN

BTK

 Inquiry

Molecular Weight: 855.98

Molecular Formula: C47H53N9O7

Density: 1.46±0.1 g/cm3

Description: It is a PROTAC that mediates the degradation of Bruton's tyrosine kinase as a therapeutic strategy for cancer.
(7S)-7-(1-(3-(4-(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)cyclohexyl)propanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide BPL-202575 (7S)-7-(1-(3-(4-(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)cyclohexyl)propanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2599848-16-3

CRBN

BTK

 Inquiry

Molecular Weight: 896.06

Molecular Formula: C50H57N9O7

Density: 1.48±0.1 g/cm3

Description: It is a PROTAC that mediates the degradation of Bruton's tyrosine kinase as a therapeutic strategy for cancer.
(7S)-7-(1-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)butanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide BPL-202576 (7S)-7-(1-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)butanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2599845-82-4

CRBN

BTK

 Inquiry

Molecular Weight: 884.98

Molecular Formula: C47H52N10O8

Density: 1.50±0.1 g/cm3

Description: It is a PROTAC that mediates the degradation of Bruton's tyrosine kinase as a therapeutic strategy for cancer.
(S)-7-(1-(3-(((1-(4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)piperidin-4-yl)methyl)(methyl)amino)cyclobutane-1-carbonyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide BPL-202577 (S)-7-(1-(3-(((1-(4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)piperidin-4-yl)methyl)(methyl)amino)cyclobutane-1-carbonyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 2599848-17-4

CRBN

BTK

 Inquiry

Molecular Weight: 842.01

Molecular Formula: C47H55N9O6

Density: 1.43±0.1 g/cm3

Description: It is a PROTAC that mediates the degradation of Bruton's tyrosine kinase as a therapeutic strategy for cancer.
1-(2-Chloro-5-(4-((1-(2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-1,6-dihydropyridin-3-yl)phenethyl)piperidin-4-yl)oxy)piperidine-1-carbonyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione BPL-202578 1-(2-Chloro-5-(4-((1-(2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-1,6-dihydropyridin-3-yl)phenethyl)piperidin-4-yl)oxy)piperidine-1-carbonyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione 2633631-78-2

CRBN

BRD9

 Inquiry

Molecular Weight: 734.29

Molecular Formula: C39H48ClN5O7

Density: 1.34±0.1 g/cm3

Description: It is a bifunctional degrader of BRD9 used in the treatment of cancer.
1-(2-Chloro-5-(4-((1-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenethyl)piperidin-4-yl)oxy)piperidine-1-carbonyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione BPL-202579 1-(2-Chloro-5-(4-((1-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenethyl)piperidin-4-yl)oxy)piperidine-1-carbonyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione 2633631-95-3

CRBN

BRD9

 Inquiry

Molecular Weight: 757.29

Molecular Formula: C40H45ClN6O7

Density: 1.40±0.1 g/cm3

Description: It is a bifunctional degrader of BRD9 used in the treatment of cancer.
1-(5-(4-((4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2-methoxyphenoxy)piperidin-1-yl)methyl)piperidine-1-carbonyl)-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione BPL-202580 1-(5-(4-((4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2-methoxyphenoxy)piperidin-1-yl)methyl)piperidine-1-carbonyl)-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione 2633632-05-8

CRBN

BRD9

 Inquiry

Molecular Weight: 755.32

Molecular Formula: C41H47ClN6O6

Density: 1.288±0.06 g/cm3

Description: It is a bifunctional degrader of BRD9 used in the treatment of cancer.
1-(5-(4-((4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenoxy)piperidin-1-yl)methyl)piperidine-1-carbonyl)-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione BPL-202581 1-(5-(4-((4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenoxy)piperidin-1-yl)methyl)piperidine-1-carbonyl)-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione 2633632-08-1

CRBN

BRD9

 Inquiry

Molecular Weight: 785.34

Molecular Formula: C42H49ClN6O7

Density: 1.287±0.06 g/cm3

Description: It is a bifunctional degrader of BRD9 used in the treatment of cancer.
1-(5-(4-(((3S,4S)-4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2-methoxyphenoxy)-3-fluoropiperidin-1-yl)methyl)piperidine-1-carbonyl)-2-methoxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione BPL-202582 1-(5-(4-(((3S,4S)-4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2-methoxyphenoxy)-3-fluoropiperidin-1-yl)methyl)piperidine-1-carbonyl)-2-methoxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione 2633632-34-3

CRBN

BRD9

 Inquiry

Molecular Weight: 768.89

Molecular Formula: C42H49FN6O7

Density: 1.35±0.1 g/cm3

Description: It is a bifunctional degrader of BRD9 used in the treatment of cancer.
1-(5-(4-(((3S,4S)-4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-difluorophenoxy)-3-fluoropiperidin-1-yl)methyl)piperidine-1-carbonyl)-2-methoxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione BPL-202583 1-(5-(4-(((3S,4S)-4-(4-(2-Butyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-difluorophenoxy)-3-fluoropiperidin-1-yl)methyl)piperidine-1-carbonyl)-2-methoxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione

CRBN

BRD9

 Inquiry

Molecular Weight: 774.84

Molecular Formula: C41H45F3N6O6

Density: 1.40±0.1 g/cm3

Description: It is a bifunctional degrader of BRD9 used in the treatment of cancer.
5-(4-(4-(3-(7-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,7-diazaspiro[2.5]octan-4-yl)benzyl)piperazine-1-carbonyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-202584 5-(4-(4-(3-(7-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,7-diazaspiro[2.5]octan-4-yl)benzyl)piperazine-1-carbonyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2641510-34-9

CRBN

SMARCA2

 Inquiry

Molecular Weight: 838.97

Molecular Formula: C46H50N10O6

Density: 1.50±0.1 g/cm3

Description: It is a bifunctional degrader of SMARCA2 used in the treatment of cancer.
5-(4-((4-(2-(3-(3-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)phenoxy)ethyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-202585 5-(4-((4-(2-(3-(3-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)phenoxy)ethyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2641508-79-2

CRBN

SMARCA2

 Inquiry

Molecular Weight: 855.01

Molecular Formula: C47H54N10O6

Density: 1.360±0.06 g/cm3

Description: It is a bifunctional degrader of SMARCA2 used in the treatment of cancer.
5-(4-(3-(4-(2-(3-(3-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)phenoxy)ethyl)piperazin-1-yl)propyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-202586 5-(4-(3-(4-(2-(3-(3-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)phenoxy)ethyl)piperazin-1-yl)propyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2641510-61-2

CRBN

SMARCA2

 Inquiry

Molecular Weight: 883.07

Molecular Formula: C49H58N10O6

Density: 1.327±0.06 g/cm3

Description: It is a bifunctional degrader of SMARCA2 used in the treatment of cancer.
3-((4-(1-(2-(4-(3-((1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)azetidin-3-yl)oxy)benzyl)piperazin-1-yl)-2-oxoethyl)piperidin-4-yl)phenyl)amino)piperidine-2,6-dione BPL-202587 3-((4-(1-(2-(4-(3-((1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)azetidin-3-yl)oxy)benzyl)piperazin-1-yl)-2-oxoethyl)piperidin-4-yl)phenyl)amino)piperidine-2,6-dione 2641510-83-8

CRBN

SMARCA2

 Inquiry

Molecular Weight: 759.91

Molecular Formula: C42H49N9O5

Boiling Point: 1013.6±65.0°C at 760 Torr

Density: 1.343±0.06 g/cm3

Description: It is a bifunctional degrader of SMARCA2 used in the treatment of cancer.
5-(4-(4-(3-(3-(3-Amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)benzyl)piperazine-1-carbonyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-202588 5-(4-(4-(3-(3-(3-Amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)benzyl)piperazine-1-carbonyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2641510-87-2

CRBN

SMARCA2

 Inquiry

Molecular Weight: 856.96

Molecular Formula: C46H49FN10O6

Density: 1.431±0.06 g/cm3

Description: It is a bifunctional degrader of SMARCA2 used in the treatment of cancer.
3-(4-(4-(1-(1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-phenylpiperidine-4-carbonyl)piperidine-4-carbonyl)piperazin-1-yl)phenyl)piperidine-2,6-dione BPL-202589 3-(4-(4-(1-(1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-phenylpiperidine-4-carbonyl)piperidine-4-carbonyl)piperazin-1-yl)phenyl)piperidine-2,6-dione 2641511-22-8

CRBN

SMARCA2

 Inquiry

Molecular Weight: 756.91

Molecular Formula: C43H48N8O5

Boiling Point: 1059.2±65.0°C at 760 Torr

Density: 1.323±0.06 g/cm3

Description: It is a bifunctional degrader of SMARCA2 used in the treatment of cancer.
N'-[3-[[5-[6-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-1-oxobutyl]-1-piperazinyl]-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide BPL-202590 N'-[3-[[5-[6-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-1-oxobutyl]-1-piperazinyl]-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide 2755772-38-2

CRBN

BRAF V600E

 Inquiry

Molecular Weight: 896.93

Molecular Formula: C43H42F2N10O8S

Density: 1.508±0.06 g/cm3

Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
N'-[3-[[5-[6-[4-[[3-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]carbonyl]-1-piperazinyl]-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide BPL-202591 N'-[3-[[5-[6-[4-[[3-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]carbonyl]-1-piperazinyl]-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide 2755772-43-9

CRBN

BRAF V600E

 Inquiry

Molecular Weight: 908.95

Molecular Formula: C44H42F2N10O8S

Density: 1.541±0.06 g/cm3

Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
N'-[3-[[5-[6-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide BPL-202592 N'-[3-[[5-[6-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide 2755772-46-2

CRBN

BRAF V600E

 Inquiry

Molecular Weight: 883.94

Molecular Formula: C43H43F2N9O8S

Density: 1.466±0.06 g/cm3

Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.

We invite you to contact us at or through our contact form above for more information about our services and products.

USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
  • Email:
Copyright © 2024 BOC Sciences. All Rights Reserved.
Inquiry Basket
Loading ......
Delete selectedGo to checkout