PROTAC Library

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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
4-(3-(4'-((3-(4-(4-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carbonyl)phenyl)prop-2-yn-1-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile BPL-202653 4-(3-(4'-((3-(4-(4-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carbonyl)phenyl)prop-2-yn-1-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 2766579-77-3

CRBN

AR

Inquiry

Molecular Weight: 950.01

Molecular Formula: C52H42F3N7O6S

Density: 1.51±0.1 g/cm3

Description: It is an enzalutamide-based PROTAC that can potently degrade androgen receptor (AR) in lung cancer cells.

4-(3-(4'-(((3R)-1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile BPL-202654 4-(3-(4'-(((3R)-1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 2766579-80-8

CRBN

AR

Inquiry

Molecular Weight: 917.97

Molecular Formula: C48H42F3N7O7S

Density: 1.53±0.1 g/cm3

Description: It is an enzalutamide-based PROTAC that can potently degrade androgen receptor (AR) in lung cancer cells.

4-(3-(4'-(((3S)-1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile BPL-202655 4-(3-(4'-(((3S)-1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 2766579-81-9

CRBN

AR

Inquiry

Molecular Weight: 917.97

Molecular Formula: C48H42F3N7O7S

Density: 1.53±0.1 g/cm3

Description: It is an enzalutamide-based PROTAC that can potently degrade androgen receptor (AR) in lung cancer cells.

L18I BPL-202656 L18I 2451070-32-7

CRBN

BTK
BTK C481A
BTK C481G
BTK C481S
BTK C481T
BTK C481W

Inquiry

Molecular Weight: 897.99

Molecular Formula: C47H51N11O8

Density: 1.46±0.1 g/cm3

Description: It is a PROTAC that degrades Bruton's tyrosine kinase mutants for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas.

GBD-2 BPL-202657 GBD-2 2864408-84-2

CRBN

BTK

Inquiry

Molecular Weight: 755.84

Molecular Formula: C41H41N9O6

Boiling Point: 1032.3±65.0°C at 760 Torr

Density: 1.48±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-3 BPL-202658 GBD-3 2864408-89-7

CRBN

BTK

Inquiry

Molecular Weight: 755.84

Molecular Formula: C41H41N9O6

Boiling Point: 1038.2±65.0°C at 760 Torr

Density: 1.48±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-4 BPL-202659 GBD-4 2864408-85-3

CRBN

BTK

Inquiry

Molecular Weight: 769.86

Molecular Formula: C42H43N9O6

Boiling Point: 1034.7±65.0°C at 760 Torr

Density: 1.46±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-5 BPL-202660 GBD-5 2864408-90-0

CRBN

BTK

Inquiry

Molecular Weight: 769.86

Molecular Formula: C42H43N9O6

Boiling Point: 1040.4±65.0°C at 760 Torr

Density: 1.46±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-7 BPL-202661 GBD-7 2864408-91-1

CRBN

BTK

Inquiry

Molecular Weight: 783.89

Molecular Formula: C43H45N9O6

Boiling Point: 1043.0±65.0°C at 760 Torr

Density: 1.45±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-8 BPL-202662 GBD-8 2429993-19-9

CRBN

BTK

Inquiry

Molecular Weight: 797.92

Molecular Formula: C44H47N9O6

Boiling Point: 1040.3±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-9 BPL-202663 GBD-9 2864408-92-2

CRBN

BTK

Inquiry

Molecular Weight: 797.92

Molecular Formula: C44H47N9O6

Boiling Point: 1045.8±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-10 BPL-202664 GBD-10 2864408-86-4

CRBN

BTK

Inquiry

Molecular Weight: 811.94

Molecular Formula: C45H49N9O6

Boiling Point: 1032.6±65.0°C at 760 Torr

Density: 1.41±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-11 BPL-202665 GBD-11 2864408-93-3

CRBN

BTK

Inquiry

Molecular Weight: 811.94

Molecular Formula: C45H49N9O6

Boiling Point: 1037.9±65.0°C at 760 Torr

Density: 1.41±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-12 BPL-202666 GBD-12 2864408-87-5

CRBN

BTK

Inquiry

Molecular Weight: 825.97

Molecular Formula: C46H51N9O6

Boiling Point: 1036.3±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-13 BPL-202667 GBD-13 2864408-94-4

CRBN

BTK

Inquiry

Molecular Weight: 825.97

Molecular Formula: C46H51N9O6

Boiling Point: 1041.5±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-14 BPL-202668 GBD-14 2864408-88-6

CRBN

BTK

Inquiry

Molecular Weight: 839.98

Molecular Formula: C47H53N9O6

Boiling Point: 1040.1±65.0°C at 760 Torr

Density: 1.39±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-15 BPL-202669 GBD-15 2864408-95-5

CRBN

BTK

Inquiry

Molecular Weight: 839.98

Molecular Formula: C47H53N9O6

Boiling Point: 1045.2±65.0°C at 760 Torr

Density: 1.39±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

GBD-16 BPL-202670 GBD-16 2864408-96-6

CRBN

BTK

Inquiry

Molecular Weight: 801.86

Molecular Formula: C42H43N9O8

Boiling Point: 1062.8±65.0°C at 760 Torr

Density: 1.49±0.1 g/cm3

Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.

3-(2-(2-(2-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-202671 3-(2-(2-(2-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide 2669833-32-1

CRBN

EGFR e19d

Inquiry

Molecular Weight: 765.19

Molecular Formula: C37H38ClFN6O9

Boiling Point: 973.3±65.0°C at 760 Torr

Density: 1.422±0.06 g/cm3

Description: It is a hypoxic-activated PROTAC that plays a more potent effect in tumor hypoxia than in normoxia.

N-(23-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21-heptaoxatricosyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-202672 N-(23-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21-heptaoxatricosyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267290-99-1

CRBN

Tau

Inquiry

Molecular Weight: 846.94

Molecular Formula: C43H54N6O12

Boiling Point: 1036.6±65.0°C at 760 Torr

Density: 1.324±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.

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