PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202653	4-(3-(4'-((3-(4-(4-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carbonyl)phenyl)prop-2-yn-1-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile	2766579-77-3	CRBN	AR	Inquiry
Molecular Weight: 950.01 Molecular Formula: C52H42F3N7O6S Density: 1.51±0.1 g/cm3 Description: It is an enzalutamide-based PROTAC that can potently degrade androgen receptor (AR) in lung cancer cells.
	BPL-202654	4-(3-(4'-(((3R)-1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile	2766579-80-8	CRBN	AR	Inquiry
Molecular Weight: 917.97 Molecular Formula: C48H42F3N7O7S Density: 1.53±0.1 g/cm3 Description: It is an enzalutamide-based PROTAC that can potently degrade androgen receptor (AR) in lung cancer cells.
	BPL-202655	4-(3-(4'-(((3S)-1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile	2766579-81-9	CRBN	AR	Inquiry
Molecular Weight: 917.97 Molecular Formula: C48H42F3N7O7S Density: 1.53±0.1 g/cm3 Description: It is an enzalutamide-based PROTAC that can potently degrade androgen receptor (AR) in lung cancer cells.
	BPL-202656	L18I	2451070-32-7	CRBN	BTK BTK C481A BTK C481G BTK C481S BTK C481T BTK C481W	Inquiry
Molecular Weight: 897.99 Molecular Formula: C47H51N11O8 Density: 1.46±0.1 g/cm3 Description: It is a PROTAC that degrades Bruton's tyrosine kinase mutants for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas.
	BPL-202657	GBD-2	2864408-84-2	CRBN	BTK	Inquiry
Molecular Weight: 755.84 Molecular Formula: C41H41N9O6 Boiling Point: 1032.3±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202658	GBD-3	2864408-89-7	CRBN	BTK	Inquiry
Molecular Weight: 755.84 Molecular Formula: C41H41N9O6 Boiling Point: 1038.2±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202659	GBD-4	2864408-85-3	CRBN	BTK	Inquiry
Molecular Weight: 769.86 Molecular Formula: C42H43N9O6 Boiling Point: 1034.7±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202660	GBD-5	2864408-90-0	CRBN	BTK	Inquiry
Molecular Weight: 769.86 Molecular Formula: C42H43N9O6 Boiling Point: 1040.4±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202661	GBD-7	2864408-91-1	CRBN	BTK	Inquiry
Molecular Weight: 783.89 Molecular Formula: C43H45N9O6 Boiling Point: 1043.0±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202662	GBD-8	2429993-19-9	CRBN	BTK	Inquiry
Molecular Weight: 797.92 Molecular Formula: C44H47N9O6 Boiling Point: 1040.3±65.0°C at 760 Torr Density: 1.43±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202663	GBD-9	2864408-92-2	CRBN	BTK	Inquiry
Molecular Weight: 797.92 Molecular Formula: C44H47N9O6 Boiling Point: 1045.8±65.0°C at 760 Torr Density: 1.43±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202664	GBD-10	2864408-86-4	CRBN	BTK	Inquiry
Molecular Weight: 811.94 Molecular Formula: C45H49N9O6 Boiling Point: 1032.6±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202665	GBD-11	2864408-93-3	CRBN	BTK	Inquiry
Molecular Weight: 811.94 Molecular Formula: C45H49N9O6 Boiling Point: 1037.9±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202666	GBD-12	2864408-87-5	CRBN	BTK	Inquiry
Molecular Weight: 825.97 Molecular Formula: C46H51N9O6 Boiling Point: 1036.3±65.0°C at 760 Torr Density: 1.40±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202667	GBD-13	2864408-94-4	CRBN	BTK	Inquiry
Molecular Weight: 825.97 Molecular Formula: C46H51N9O6 Boiling Point: 1041.5±65.0°C at 760 Torr Density: 1.40±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202668	GBD-14	2864408-88-6	CRBN	BTK	Inquiry
Molecular Weight: 839.98 Molecular Formula: C47H53N9O6 Boiling Point: 1040.1±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202669	GBD-15	2864408-95-5	CRBN	BTK	Inquiry
Molecular Weight: 839.98 Molecular Formula: C47H53N9O6 Boiling Point: 1045.2±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202670	GBD-16	2864408-96-6	CRBN	BTK	Inquiry
Molecular Weight: 801.86 Molecular Formula: C42H43N9O8 Boiling Point: 1062.8±65.0°C at 760 Torr Density: 1.49±0.1 g/cm3 Description: It is a molecule that combines PROTAC and molecular gel for degrading BTK and GSPT1 proteins concurrently.
	BPL-202671	3-(2-(2-(2-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide	2669833-32-1	CRBN	EGFR e19d	Inquiry
Molecular Weight: 765.19 Molecular Formula: C37H38ClFN6O9 Boiling Point: 973.3±65.0°C at 760 Torr Density: 1.422±0.06 g/cm3 Description: It is a hypoxic-activated PROTAC that plays a more potent effect in tumor hypoxia than in normoxia.
	BPL-202672	N-(23-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21-heptaoxatricosyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide	2267290-99-1	CRBN	Tau	Inquiry
Molecular Weight: 846.94 Molecular Formula: C43H54N6O12 Boiling Point: 1036.6±65.0°C at 760 Torr Density: 1.324±0.06 g/cm3 Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cells-derived euronal models of tauopathy.