| Structure |
Catalog |
Product Name |
CAS |
E3 Ligase |
Target |
Inquiry |
![N'-[3-[[5-[2-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]-5-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide](https://resource.bocsci.com/structure/2755772-54-2.gif) |
BPL-202593 |
N'-[3-[[5-[2-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]-5-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide |
2755772-54-2 |
CRBN |
BRAF V600E |
Inquiry |
|
Molecular Weight: 884.92
Molecular Formula: C42H42F2N10O8S
Density: 1.485±0.06 g/cm3
Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
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![N'-[3-[[5-[4-[4-[[3-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]carbonyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide](https://resource.bocsci.com/structure/2755772-64-4.gif) |
BPL-202594 |
N'-[3-[[5-[4-[4-[[3-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]carbonyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide |
2755772-64-4 |
CRBN |
BRAF V600E |
Inquiry |
|
Molecular Weight: 907.96
Molecular Formula: C45H43F2N9O8S
Density: 1.522±0.06 g/cm3
Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
|
![N'-[3-[[5-[4-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide](https://resource.bocsci.com/structure/2755772-65-5.gif) |
BPL-202595 |
N'-[3-[[5-[4-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide |
2755772-65-5 |
CRBN |
BRAF V600E |
Inquiry |
|
Molecular Weight: 882.95
Molecular Formula: C44H44F2N8O8S
Density: 1.448±0.06 g/cm3
Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
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 |
BPL-202596 |
(Nonane-1,9-diylbis(piperazine-4,1-diyl))bis((2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazol-1-yl)methanone) |
2415935-39-4 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1283.37
Molecular Formula: C73H88Cl4N8O4
Density: 1.23±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202597 |
1,7-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)heptane-1,7-dione |
2415935-38-3 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1283.28
Molecular Formula: C71H80Cl4N8O6
Density: 1.28±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202598 |
1,9-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)nonane-1,9-dione |
2415935-40-7 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1311.34
Molecular Formula: C73H84Cl4N8O6
Density: 1.26±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202599 |
1,11-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)undecane-1,11-dione |
2415935-41-8 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1339.39
Molecular Formula: C75H88Cl4N8O6
Density: 1.25±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202600 |
1,16-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)hexadecane-1,16-dione |
2415935-45-2 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1409.53
Molecular Formula: C80H98Cl4N8O6
Density: 1.23±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202601 |
2,2'-(Ethane-1,2-diylbis(oxy))bis(1-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one) |
2415935-43-0 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1301.25
Molecular Formula: C70H78Cl4N8O8
Density: 1.30±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202602 |
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(1-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one) |
2415935-44-1 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1345.31
Molecular Formula: C72H82Cl4N8O9
Density: 1.29±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202603 |
N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) |
2415935-35-0 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1459.41
Molecular Formula: C76H88Cl4N10O11
Density: 1.32±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202604 |
N,N'-((Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) |
2415935-36-1 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1415.36
Molecular Formula: C74H84Cl4N10O10
Density: 1.32±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202605 |
N,N'-(Oxybis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) |
2415935-37-2 |
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1371.31
Molecular Formula: C72H80Cl4N10O9
Density: 1.33±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202606 |
N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) |
|
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1459.41
Molecular Formula: C76H88Cl4N10O11
Density: 1.32±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202607 |
N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-((4R,5S)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) |
|
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1459.41
Molecular Formula: C76H88Cl4N10O11
Density: 1.32±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
 |
BPL-202608 |
2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-N-(1-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)acetamide |
|
MDM2 |
MDM2 |
Inquiry |
|
Molecular Weight: 1459.41
Molecular Formula: C76H88Cl4N10O11
Density: 1.32±0.1 g/cm3
Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
|
![3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide](https://resource.bocsci.com/structure/2703834-31-3.gif) |
BPL-202609 |
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide |
2703834-31-3 |
CRBN |
BCR-ABL T315I |
Inquiry |
|
Molecular Weight: 933.95
Molecular Formula: C48H46F3N9O8
Boiling Point: 1032.5±65.0°C at 760 Torr
Density: 1.49±0.1 g/cm3
Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
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![3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide](https://resource.bocsci.com/structure/2703834-36-8.gif) |
BPL-202610 |
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide |
2703834-36-8 |
CRBN |
BCR-ABL T315I |
Inquiry |
|
Molecular Weight: 919.96
Molecular Formula: C48H48F3N9O7
Boiling Point: 1038.6±65.0°C at 760 Torr
Density: 1.46±0.1 g/cm3
Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
|
![3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide](https://resource.bocsci.com/structure/2703834-37-9.gif) |
BPL-202611 |
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide |
2703834-37-9 |
CRBN |
BCR-ABL T315I |
Inquiry |
|
Molecular Weight: 906.92
Molecular Formula: C47H45F3N8O8
Boiling Point: 981.9±65.0°C at 760 Torr
Density: 1.48±0.1 g/cm3
Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
|
![(2S,4R)-1-((S)-2-(3-(2-(2-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2703834-18-6.gif) |
BPL-202612 |
(2S,4R)-1-((S)-2-(3-(2-(2-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
2703834-18-6 |
VHL |
BCR-ABL T315I |
Inquiry |
|
Molecular Weight: 1091.25
Molecular Formula: C57H65F3N10O7S
Boiling Point: 1135.8±65.0°C at 760 Torr
Density: 1.38±0.1 g/cm3
Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
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