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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
N'-[3-[[5-[2-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]-5-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide BPL-202593 N'-[3-[[5-[2-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]-5-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide 2755772-54-2

CRBN

BRAF V600E

 Inquiry

Molecular Weight: 884.92

Molecular Formula: C42H42F2N10O8S

Density: 1.485±0.06 g/cm3

Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
N'-[3-[[5-[4-[4-[[3-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]carbonyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide BPL-202594 N'-[3-[[5-[4-[4-[[3-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]carbonyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide 2755772-64-4

CRBN

BRAF V600E

 Inquiry

Molecular Weight: 907.96

Molecular Formula: C45H43F2N9O8S

Density: 1.522±0.06 g/cm3

Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
N'-[3-[[5-[4-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide BPL-202595 N'-[3-[[5-[4-[4-[4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]-1-oxobutyl]-1-piperazinyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide 2755772-65-5

CRBN

BRAF V600E

 Inquiry

Molecular Weight: 882.95

Molecular Formula: C44H44F2N8O8S

Density: 1.448±0.06 g/cm3

Description: It is a heterobifunctional degrader of BRAF V600E used in the treatment of cancer.
(Nonane-1,9-diylbis(piperazine-4,1-diyl))bis((2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazol-1-yl)methanone) BPL-202596 (Nonane-1,9-diylbis(piperazine-4,1-diyl))bis((2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazol-1-yl)methanone) 2415935-39-4

MDM2

MDM2

 Inquiry

Molecular Weight: 1283.37

Molecular Formula: C73H88Cl4N8O4

Density: 1.23±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
1,7-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)heptane-1,7-dione BPL-202597 1,7-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)heptane-1,7-dione 2415935-38-3

MDM2

MDM2

 Inquiry

Molecular Weight: 1283.28

Molecular Formula: C71H80Cl4N8O6

Density: 1.28±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
1,9-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)nonane-1,9-dione BPL-202598 1,9-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)nonane-1,9-dione 2415935-40-7

MDM2

MDM2

 Inquiry

Molecular Weight: 1311.34

Molecular Formula: C73H84Cl4N8O6

Density: 1.26±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
1,11-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)undecane-1,11-dione BPL-202599 1,11-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)undecane-1,11-dione 2415935-41-8

MDM2

MDM2

 Inquiry

Molecular Weight: 1339.39

Molecular Formula: C75H88Cl4N8O6

Density: 1.25±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
1,16-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)hexadecane-1,16-dione BPL-202600 1,16-Bis(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)hexadecane-1,16-dione 2415935-45-2

MDM2

MDM2

 Inquiry

Molecular Weight: 1409.53

Molecular Formula: C80H98Cl4N8O6

Density: 1.23±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
2,2'-(Ethane-1,2-diylbis(oxy))bis(1-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one) BPL-202601 2,2'-(Ethane-1,2-diylbis(oxy))bis(1-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one) 2415935-43-0

MDM2

MDM2

 Inquiry

Molecular Weight: 1301.25

Molecular Formula: C70H78Cl4N8O8

Density: 1.30±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(1-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one) BPL-202602 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(1-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)ethan-1-one) 2415935-44-1

MDM2

MDM2

 Inquiry

Molecular Weight: 1345.31

Molecular Formula: C72H82Cl4N8O9

Density: 1.29±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) BPL-202603 N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) 2415935-35-0

MDM2

MDM2

 Inquiry

Molecular Weight: 1459.41

Molecular Formula: C76H88Cl4N10O11

Density: 1.32±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
N,N'-((Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) BPL-202604 N,N'-((Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) 2415935-36-1

MDM2

MDM2

 Inquiry

Molecular Weight: 1415.36

Molecular Formula: C74H84Cl4N10O10

Density: 1.32±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
N,N'-(Oxybis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) BPL-202605 N,N'-(Oxybis(ethane-2,1-diyl))bis(2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) 2415935-37-2

MDM2

MDM2

 Inquiry

Molecular Weight: 1371.31

Molecular Formula: C72H80Cl4N10O9

Density: 1.33±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) BPL-202606 N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide)

MDM2

MDM2

 Inquiry

Molecular Weight: 1459.41

Molecular Formula: C76H88Cl4N10O11

Density: 1.32±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-((4R,5S)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide) BPL-202607 N,N'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(2-(4-((4R,5S)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide)

MDM2

MDM2

 Inquiry

Molecular Weight: 1459.41

Molecular Formula: C76H88Cl4N10O11

Density: 1.32±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-N-(1-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)acetamide BPL-202608 2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-N-(1-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)acetamide

MDM2

MDM2

 Inquiry

Molecular Weight: 1459.41

Molecular Formula: C76H88Cl4N10O11

Density: 1.32±0.1 g/cm3

Description: It is a homo-PROTAC that induces self-degradation of MDM2 for the treatment of non-small cell lung cancer.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202609 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-31-3

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 933.95

Molecular Formula: C48H46F3N9O8

Boiling Point: 1032.5±65.0°C at 760 Torr

Density: 1.49±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202610 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-36-8

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 919.96

Molecular Formula: C48H48F3N9O7

Boiling Point: 1038.6±65.0°C at 760 Torr

Density: 1.46±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202611 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-37-9

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 906.92

Molecular Formula: C47H45F3N8O8

Boiling Point: 981.9±65.0°C at 760 Torr

Density: 1.48±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
(2S,4R)-1-((S)-2-(3-(2-(2-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202612 (2S,4R)-1-((S)-2-(3-(2-(2-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2703834-18-6

VHL

BCR-ABL T315I

 Inquiry

Molecular Weight: 1091.25

Molecular Formula: C57H65F3N10O7S

Boiling Point: 1135.8±65.0°C at 760 Torr

Density: 1.38±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.

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