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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-((11S,14S,15R)-15-amino-14-hydroxy-11-isobutyl-10,13-dioxo-16-phenyl-3,6-dioxa-9,12-diazahexadecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202613 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-((11S,14S,15R)-15-amino-14-hydroxy-11-isobutyl-10,13-dioxo-16-phenyl-3,6-dioxa-9,12-diazahexadecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-20-0

cIAP1

BCR-ABL T315I

 Inquiry

Molecular Weight: 940.08

Molecular Formula: C50H60F3N9O6

Boiling Point: 1037.6±65.0°C at 760 Torr

Density: 1.33±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202614 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-30-2

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 889.89

Molecular Formula: C46H42F3N9O7

Boiling Point: 1012.0±65.0°C at 760 Torr

Density: 1.51±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202615 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(2-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-32-4

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 977.98

Molecular Formula: C50H50F3N9O9

Boiling Point: 1052.9±65.0°C at 760 Torr

Density: 1.47±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
1-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxapentadecan-15-amide BPL-202616 1-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxapentadecan-15-amide 2703834-33-5

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 1022.05

Molecular Formula: C52H54F3N9O10

Boiling Point: 1073.2±65.0°C at 760 Torr

Density: 1.45±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
1-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide BPL-202617 1-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide 2703834-34-6

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 1066.09

Molecular Formula: C54H58F3N9O11

Boiling Point: 1093.4±65.0°C at 760 Torr

Density: 1.44±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
1-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-amide BPL-202618 1-(4-(4-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methylbenzamido)-2-(trifluoromethyl)benzyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-amide 2703834-35-7

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 1110.16

Molecular Formula: C56H62F3N9O12

Boiling Point: 1113.4±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202619 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-21-1

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 845.84

Molecular Formula: C44H38F3N9O6

Boiling Point: 998.8±65.0°C at 760 Torr

Density: 1.53±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-5-oxopentyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202620 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-5-oxopentyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-22-2

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 873.89

Molecular Formula: C46H42F3N9O6

Boiling Point: 1007.9±65.0°C at 760 Torr

Density: 1.50±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-6-oxohexyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202621 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-6-oxohexyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-24-4

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 887.92

Molecular Formula: C47H44F3N9O6

Boiling Point: 1012.2±65.0°C at 760 Torr

Density: 1.48±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-7-oxoheptyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202622 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-7-oxoheptyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-25-5

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 901.95

Molecular Formula: C48H46F3N9O6

Boiling Point: 1016.7±65.0°C at 760 Torr

Density: 1.46±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-9-oxononyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202623 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-9-oxononyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-26-6

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 929.99

Molecular Formula: C50H50F3N9O6

Boiling Point: 1026.0±65.0°C at 760 Torr

Density: 1.44±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-11-oxoundecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202624 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-11-oxoundecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-27-7

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 958.06

Molecular Formula: C52H54F3N9O6

Boiling Point: 1030.3±65.0°C at 760 Torr

Density: 1.41±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(13-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-13-oxotridecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202625 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(13-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-13-oxotridecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-28-8

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 986.11

Molecular Formula: C54H58F3N9O6

Boiling Point: 1040.6±65.0°C at 760 Torr

Density: 1.38±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(15-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-15-oxopentadecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide BPL-202626 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-N-(4-((4-(15-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-15-oxopentadecyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide 2703834-29-9

CRBN

BCR-ABL T315I

 Inquiry

Molecular Weight: 1014.16

Molecular Formula: C56H62F3N9O6

Boiling Point: 1051.1±65.0°C at 760 Torr

Density: 1.36±0.1 g/cm3

Description: It is a selective BCR-ABL T315I proteolysis-targeting chimeric (PROTAC) degrader based on GZD824.
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (3-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)ethoxy)ethoxy)propyl)carbamate BPL-202627 (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (3-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)ethoxy)ethoxy)propyl)carbamate 2715104-40-6

CRBN

HMGCR

 Inquiry

Molecular Weight: 822.95

Molecular Formula: C43H58N4O12

Boiling Point: 1002.3±65.0°C at 760 Torr

Density: 1.32±0.1 g/cm3

Description: It is an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo.
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)carbamate BPL-202628 (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)carbamate 2715104-41-7

CRBN

HMGCR

 Inquiry

Molecular Weight: 750.85

Molecular Formula: C39H50N4O11

Boiling Point: 978.5±65.0°C at 760 Torr

Density: 1.36±0.1 g/cm3

Description: It is an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo.
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)carbamate BPL-202629 (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)carbamate 2715104-42-8

CRBN

HMGCR

 Inquiry

Molecular Weight: 676.77

Molecular Formula: C36H44N4O9

Boiling Point: 945.9±65.0°C at 760 Torr

Density: 1.37±0.1 g/cm3

Description: It is an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo.
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (8-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctyl)carbamate BPL-202630 (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (8-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctyl)carbamate 2715104-44-0

VHL

HMGCR

 Inquiry

Molecular Weight: 918.21

Molecular Formula: C50H71N5O9S

Boiling Point: 1106.0±65.0°C at 760 Torr

Density: 1.25±0.1 g/cm3

Description: It is an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo.
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)carbamate BPL-202631 (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)carbamate 2715104-45-1

VHL

HMGCR

 Inquiry

Molecular Weight: 960.29

Molecular Formula: C53H77N5O9S

Boiling Point: 1113.1±65.0°C at 760 Torr

Density: 1.23±0.1 g/cm3

Description: It is an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo.
(3R,5R)-3,5-Dihydroxy-7-((1S,2S,6R,8S,8aR)-8-(((11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)carbamoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid BPL-202632 (3R,5R)-3,5-Dihydroxy-7-((1S,2S,6R,8S,8aR)-8-(((11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)carbamoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid 2715104-46-2

VHL

HMGCR

 Inquiry

Molecular Weight: 978.31

Molecular Formula: C53H79N5O10S

Boiling Point: 1141.4±65.0°C at 760 Torr

Density: 1.24±0.1 g/cm3

Description: It is an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo.

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