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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(11-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)malonamide BPL-201373 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(11-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)malonamide 2458219-54-8

VHL

SHP2

 Inquiry

Molecular Weight: 1060.83

Molecular Formula: C53H74ClN11O6S2

Boiling Point: 1221.9±65.0°C at 760 Torr

Density: 1.32±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(12-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecyl)malonamide BPL-201374 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(12-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecyl)malonamide 2458219-55-9

VHL

SHP2

 Inquiry

Molecular Weight: 1074.86

Molecular Formula: C54H76ClN11O6S2

Boiling Point: 1225.2±65.0°C at 760 Torr

Density: 1.31±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(11-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)succinamide BPL-201375 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(11-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)succinamide 2458219-56-0

VHL

SHP2

 Inquiry

Molecular Weight: 1074.86

Molecular Formula: C54H76ClN11O6S2

Boiling Point: 1229.8±65.0°C at 760 Torr

Density: 1.31±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecyl)succinamide BPL-201376 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecyl)succinamide 2458219-57-1

VHL

SHP2

 Inquiry

Molecular Weight: 1088.89

Molecular Formula: C55H78ClN11O6S2

Boiling Point: 1233.1±65.0°C at 760 Torr

Density: 1.30±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N5-(12-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecyl)glutaramide BPL-201377 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N5-(12-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecyl)glutaramide 2458219-58-2

VHL

SHP2

 Inquiry

Molecular Weight: 1102.91

Molecular Formula: C56H80ClN11O6S2

Boiling Point: 1239.2±65.0°C at 760 Torr

Density: 1.29±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-((S)-13-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl)succinamide BPL-201378 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-((S)-13-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl)succinamide 2458219-59-3

VHL

SHP2

 Inquiry

Molecular Weight: 1080.78

Molecular Formula: C51H70ClN11O9S2

Boiling Point: 1250.2±65.0°C at 760 Torr

Density: 1.37±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-((S)-14-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)succinamide BPL-201379 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-((S)-14-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)succinamide 2458219-60-6

VHL

SHP2

 Inquiry

Molecular Weight: 1094.80

Molecular Formula: C52H72ClN11O9S2

Boiling Point: 1257.8±65.0°C at 760 Torr

Density: 1.36±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-((S)-17-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-18,18-dimethyl-15-oxo-3,6,9,12-tetraoxa-16-azanonadecyl)succinamide BPL-201380 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-((S)-17-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-18,18-dimethyl-15-oxo-3,6,9,12-tetraoxa-16-azanonadecyl)succinamide

VHL

SHP2

 Inquiry

Molecular Weight: 1138.86

Molecular Formula: C54H76ClN11O10S2

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
(2S,4R)-1-((S)-2-(11-(4-(2-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-2-oxoethyl)piperazin-1-yl)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201381 (2S,4R)-1-((S)-2-(11-(4-(2-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-2-oxoethyl)piperazin-1-yl)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2458219-62-8

VHL

SHP2

 Inquiry

Molecular Weight: 1101.93

Molecular Formula: C56H81ClN12O5S2

Boiling Point: 1195.5±65.0°C at 760 Torr

Density: 1.31±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
(2S,4R)-1-((S)-2-(12-(4-(2-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-2-oxoethyl)piperazin-1-yl)dodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201382 (2S,4R)-1-((S)-2-(12-(4-(2-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-2-oxoethyl)piperazin-1-yl)dodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2458219-63-9

VHL

SHP2

 Inquiry

Molecular Weight: 1115.96

Molecular Formula: C57H83ClN12O5S2

Boiling Point: 1199.6±65.0°C at 760 Torr

Density: 1.30±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N16-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)hexadecanediamide BPL-201383 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N16-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)hexadecanediamide 2458219-64-0

VHL

SHP2

 Inquiry

Molecular Weight: 1059.89

Molecular Formula: C55H79ClN10O5S2

Boiling Point: 1166.6±65.0°C at 760 Torr

Density: 1.27±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
(2S,4R)-1-((S)-2-(10-(4-(4-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201384 (2S,4R)-1-((S)-2-(10-(4-(4-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2458219-66-2

VHL

SHP2

 Inquiry

Molecular Weight: 1129.94

Molecular Formula: C57H81ClN12O6S2

Boiling Point: 1238.5±65.0°C at 760 Torr

Density: 1.32±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(4-((8-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctyl)oxy)phenyl)succinamide BPL-201385 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(4-((8-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctyl)oxy)phenyl)succinamide 2458219-67-3

VHL

SHP2

 Inquiry

Molecular Weight: 1124.88

Molecular Formula: C57H74ClN11O7S2

Boiling Point: 1280.3±65.0°C at 760 Torr

Density: 1.35±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(4-(4-(5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)piperazin-1-yl)butyl)succinamide BPL-201386 N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(4-(4-(5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)piperazin-1-yl)butyl)succinamide 2458219-68-4

VHL

SHP2

 Inquiry

Molecular Weight: 1130.93

Molecular Formula: C56H80ClN13O6S2

Boiling Point: 1277.2±65.0°C at 760 Torr

Density: 1.34±0.1 g/cm3

Description: It is a potent and effective PROTAC degrader of SHP2 protein.
Azo-PROTAC-2C BPL-201387 Azo-PROTAC-2C 2377513-19-2

CRBN

BCR-ABL

 Inquiry

Molecular Weight: 953.49

Molecular Formula: C48H45ClN12O6S

Density: 1.50±0.1 g/cm3

Description: It is an Azo-PROTAC that is a light-controlled small-molecule tool used for protein knockdown in cells.
Azo-PROTAC-3C BPL-201388 Azo-PROTAC-3C 2377513-20-5

CRBN

BCR-ABL

 Inquiry

Molecular Weight: 967.51

Molecular Formula: C49H47ClN12O6S

Density: 1.48±0.1 g/cm3

Description: It is an Azo-PROTAC that is a light-controlled small-molecule tool used for protein knockdown in cells.
Azo-PROTAC-4C BPL-201389 Azo-PROTAC-4C 2377513-21-6

CRBN

BCR-ABL

 Inquiry

Molecular Weight: 981.54

Molecular Formula: C50H49ClN12O6S

Density: 1.47±0.1 g/cm3

Description: It is an Azo-PROTAC that is a light-controlled small-molecule tool used for protein knockdown in cells.
Azo-PROTAC-5C BPL-201390 Azo-PROTAC-5C 2377513-22-7

CRBN

BCR-ABL

 Inquiry

Molecular Weight: 995.57

Molecular Formula: C51H51ClN12O6S

Density: 1.45±0.1 g/cm3

Description: It is an Azo-PROTAC that is a light-controlled small-molecule tool used for protein knockdown in cells.
Azo-PROTAC-6C BPL-201391 Azo-PROTAC-6C 2377513-23-8

CRBN

BCR-ABL

 Inquiry

Molecular Weight: 1009.59

Molecular Formula: C52H53ClN12O6S

Density: 1.44±0.1 g/cm3

Description: It is an Azo-PROTAC that is a light-controlled small-molecule tool used for protein knockdown in cells.
photoPROTAC-1 BPL-201392 photoPROTAC-1 2376993-56-3

VHL

BRD2

 Inquiry

Molecular Weight: 1108.65

Molecular Formula: C54H50ClF4N11O5S2

Density: 1.49±0.1 g/cm3

Description: It is a bistable photoswitchable PROTAC (photoPROTAC) that induces protein degradation.

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