Aminooxy-PEG7-methane
CAS No.: 1370698-27-3
Cat No.: BP-500711
Purity: ≥95%
4.5 
Aminooxy-PEG7-methane is a heterobifunctional PEG-based linker featuring an aminooxy (hydroxylamine) reactive group at one terminus and a terminal methylene handle at the other, connected through a seven-unit polyethylene glycol chain. The aminooxy functionality enables chemoselective oxime-bond formation with aldehyde-bearing targeting ligands or biomolecules under mild aqueous conditions, while the PEG spacer provides hydrophilicity and conformational flexibility to reduce steric hindrance and improve effective proximity between the recruited components. In PROTAC and targeted protein degradation workflows, this linker is used to conjugate or functionalize one end of the molecular architecture, allowing researchers to attach ligands (e.g., small-molecule binders or peptide-derived targeting elements) through stable oxime linkages while maintaining a spacer length compatible with ternary complex formation. Its PEG7 character makes it a practical building block for tuning solubility, linker accessibility, and overall degradation construct performance in iterative structure–activity studies.
Structure of 1370698-27-3
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Aminooxy-PEG7-methane is a PEG-based linker bearing an aminooxy functional group, designed to enable efficient conjugation strategies commonly used in PROTAC construction. Its flexible, hydrophilic ether-rich scaffold can help tune linker length, solubility, and conformational behavior between the ligand-binding and E3-recruiting modules. The aminooxy handle supports chemoselective oxime formation, facilitating robust assembly of targeted protein degraders. The structure and reactivity considerations for experimental use are described in detail below.
Structure: The linker consists of a poly(ethylene glycol) ether chain terminated with an aminooxy group and a saturated methane-based linkage. It features multiple ether linkages that confer flexibility and water compatibility, alongside an aminooxy functionality capable of forming oxime linkages under mild conditions.
Reactivity: Aminooxy-PEG7-methane is suited for oxime ligation with aldehyde-bearing partners, proceeding via nucleophilic addition to form an oxime under controlled pH. Typical conditions employ aqueous or mixed aqueous/organic solvents with mild base or acid catalysis, while minimizing competing nucleophiles. No specialized catalysts are generally required; reaction progress is monitored by analytical methods commonly used for oxime formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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