Biotin-PEG11-oxyamine
Cat No.: BP-501837
4.5 
Biotin-PEG11-oxyamine is a biotin-functionalized polyethylene glycol linker bearing a terminal oxyamine group, providing a flexible, hydrophilic spacer between a biotin recognition element and a carbonyl-reactive handle. The PEG11 chain length and ether-rich backbone help reduce steric hindrance and improve solubility, while the oxyamine functionality enables formation of stable oxime or related conjugates with carbonyl-containing partners under commonly used bioconjugation conditions. In PROTAC and targeted degradation workflows, this type of linker can be used to attach a biotin tag for affinity capture or to route the construct through streptavidin-based enrichment, facilitating downstream analysis such as pull-down of ternary complexes or monitoring of degradation pathway engagement. Its modular design supports experimental optimization of linker length and attachment chemistry, improving the reliability of assays that require selective capture, purification, or characterization of degradation intermediates.
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* For research and manufacturing use only. Not for human or clinical use.
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Biotin-PEG11-oxyamine is a polyethylene glycol-based PROTAC linker designed to connect a biotin handle to an amine-reactive terminus, supporting modular assembly of targeted protein degradation constructs. Its PEG scaffold provides conformational flexibility and improved solubility, while the oxyamine functionality enables chemoselective coupling strategies compatible with bifunctional ligands. The molecule is well suited for researchers developing biotin-tagged or affinity-enabled PROTACs, where the linker must maintain effective spatial presentation of both binding and recruiting elements. Detailed structural and reactivity considerations are provided below.
Structure: Biotin-PEG11-oxyamine features a biotin moiety tethered to an extended PEG chain terminated by an oxyamine group. The linker contains ether linkages within the PEG segment and an oxyamine functionality capable of forming stable covalent intermediates during coupling. Overall, it is typically characterized by high polarity and water-compatible behavior.
Reactivity: The oxyamine terminus is commonly used in PROTAC linker chemistry to enable controlled formation of amide or related conjugates via nucleophilic substitution and condensation-type pathways, depending on the partner functional group. Suitable conditions generally rely on buffered aqueous or mixed solvent systems at mild temperatures, with coupling promoted by standard activating reagents for the complementary group. Reaction progress is typically monitored by chromatographic or spectroscopic methods to ensure selective, high-yield assembly of the bifunctional construct.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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