Biotin-PEG23-amine
Cat No.: BP-501984
4.5 
Biotin-PEG23-amine is a heterobifunctional PEG-based linker featuring a biotin moiety at one terminus and a primary amine at the other, separated by a long, flexible polyethylene glycol chain that provides aqueous solubility and spatial reach. The PEG segment acts as a hydrophilic spacer to reduce steric interference and to improve the accessibility of the biotin for avidin or streptavidin binding, while the terminal amine enables straightforward conjugation to activated carboxyl groups, NHS-esters, isothiocyanates, or other electrophiles commonly used to attach PROTAC-relevant ligands. In targeted protein degradation workflows, this linker can be used to generate biotin-tagged PROTAC constructs for affinity capture, immobilized assay formats, or pull-down experiments that monitor ternary complex formation and degradation kinetics. Its extended length and flexible architecture make it particularly useful when maintaining effective geometry between the recruiter and E3 ligase–binding components is critical for functional activity.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Popular Publications Citing BOC Sciences Products
Biotin-PEG23-amine is a PEG-based linker bearing a terminal primary amine and a biotin handle, designed to support modular construction of PROTACs and related targeted protein degradation tools. Its flexible, hydrophilic PEG segment can help tune linker length and conformational dynamics, while the amine enables reliable conjugation to electrophilic warheads or activated carboxyl derivatives. The biotin moiety provides an additional affinity tag useful for downstream handling, immobilization, or analytical workflows. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a biotin group connected through an extended poly(ethylene glycol) chain terminating in a primary amine. It contains amide-like heteroatom environments, ether linkages within the PEG backbone, and a reactive aliphatic amine. Overall, it is highly polar and water-compatible, with conformational flexibility that can reduce steric constraints in conjugates.
Reactivity: The terminal primary amine is suited for amide-bond formation via coupling to activated carboxylic acids (for example, NHS esters, activated esters, or acid chlorides) under standard peptide-coupling conditions. Alternatively, it can participate in urea or carbamate-forming reactions when paired with isocyanates or activated carbonyl derivatives. Typical approaches use polar aprotic solvents and base to promote nucleophilic acyl substitution, enabling efficient PROTAC assembly through stable covalent linkage formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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