Name: Biotin-PEG3-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>97%

Solubility

In DMSO: 100 mg/mL (223.44 mM; Need ultrasonic)

Appearance

White Powder

Storage

4°C, sealed storage, away from moisture; In solvent, -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

3-[2-[2-[2-[[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]propanoic acid; 3-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]propanoic acid

Boiling Point

770.7±60.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

HRGPPBXEZFBGDJ-MPGHIAIKSA-N

InChI

InChI=1S/C19H33N3O7S/c23-16(4-2-1-3-15-18-14(13-30-15)21-19(26)22-18)20-6-8-28-10-12-29-11-9-27-7-5-17(24)25/h14-15,18H,1-13H2,(H,20,23)(H,24,25)(H2,21,22,26)/t14-,15-,18-/m0/s1

SMILES

C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCC(=O)O)NC(=O)N2

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.2344 mL	11.1719 mL	22.3439 mL
5 mM	0.4469 mL	2.2344 mL	4.4688 mL
10 mM	0.2234 mL	1.1172 mL	2.2344 mL

Biotin-PEG3-propionic acid is a biotinylated PEG acid linker for preparing affinity-enabled PROTAC probes and linker conjugates. The PEG spacer separates the biotin recognition unit from the coupling site, supporting reduced steric interference in pull-down or probe-oriented degrader studies. Details are provided below.

Structure: The molecule contains a biotin moiety, an oligoethylene glycol spacer, and a terminal propionic acid group. It includes ureido, thioether, ether, amide, and carboxylic acid functionalities.

Reactivity: The terminal acid can be activated for amide formation with amine-bearing ligands or converted into activated ester intermediates for staged conjugation. Coupling should use conditions that preserve the biotin core and sulfur-containing functionality. This linker is most appropriate for affinity-tagged PROTAC probes rather than untagged degrader backbones.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂