Bis-Mal-PEG19
Cat No.: BP-501733
4.5 
Bis-Mal-PEG19 is a homobifunctional, bis-maleimide–terminated polyethylene glycol linker designed for thiol-reactive conjugation in PROTAC and targeted protein degradation workflows. Structurally, it consists of a long, flexible PEG19 spacer flanked by two maleimide groups, enabling simultaneous or sequential coupling to cysteine-containing ligands or engineered protein-binding modules via stable thioether formation. In PROTAC architectures, this linker can bridge two functional components—such as an E3 ligase binder and a target-binding moiety—while the PEG chain provides conformational flexibility and improved aqueous solubility, often helping maintain productive geometry for ternary complex formation. Its bis-reactivity supports modular synthesis of multi-component degraders, facilitating systematic variation of linker length and attachment stoichiometry. For researchers, Bis-Mal-PEG19 is a practical tool for constructing degraders with defined, cysteine-directed connectivity and for optimizing degradation potency through linker-driven tuning of spatial arrangement and pharmacokinetic-relevant solubility properties.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-Mal-PEG19 is a bifunctional, PEG-based linker designed for assembling PROTACs through efficient conjugation to two targeting ligands. Its flexible hydrophilic scaffold can help modulate solubility and spatial presentation of warheads, which is often critical for productive ternary complex formation and targeted protein degradation. The following sections describe its structure and practical reactivity considerations in detail.
Structure: The molecule is a long-chain polyethylene glycol (PEG) scaffold bearing two maleimide functionalities. The maleimide groups provide electrophilic alkene sites, while the ether-rich PEG segment confers conformational flexibility and hydrophilicity. The linker contains stable C–N and C–O frameworks alongside reactive C=C within the maleimide rings.
Reactivity: Bis-Mal-PEG19 is typically used in thiol–maleimide conjugation, where nucleophilic sulfhydryl groups add across the maleimide double bond to form a stable thioether linkage. Suitable conditions generally employ aqueous or mixed aqueous buffers near neutral pH, with careful control to minimize competing hydrolysis of maleimides. Common approaches include preparing thiol-bearing ligands (e.g., via reduction of protected thiols) and reacting them with the linker without strong nucleophiles or oxidants that could impair thiol availability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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