Bis-PEG3-t-butyl ester
CAS No.: 1611468-29-1
Cat No.: BP-500716
Purity: ≥95%
4.5 
Bis-PEG3-t-butyl ester is a bifunctional polyethylene glycol linker bearing two PEG3 arms terminated with tert-butyl ester groups. Structurally, it provides a flexible, hydrophilic spacer that can project two conjugation handles away from bulky warhead or ligand scaffolds, while the ester termini serve as chemically addressable sites for subsequent functionalization (e.g., conversion to carboxylates or activation for amide/ester coupling). In PROTAC design, such bis-PEG linkers are used to connect two recognition elements or to couple a ligand to a reactive degradation handle, improving effective reach and reducing steric hindrance at the formation of the ternary complex. The PEG backbone also helps modulate solubility and can influence degradation kinetics by affecting the conformational freedom and local presentation of binding motifs. This linker is therefore valuable for constructing modular targeted protein degradation reagents and for optimizing linker length and geometry during iterative structure–activity studies.
Structure of 1611468-29-1
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Bis-PEG3-t-butyl ester, is designed to provide a polyethylene glycol (PEG)-based spacer that improves solubility and conformational flexibility while supporting efficient conjugation to target-binding ligands. Its ester functionality enables controlled chemical coupling strategies commonly used in targeted protein degradation workflows. The features and reactivity described below will help guide linker selection and assembly for PROTAC constructs.
Structure: The linker contains a PEG-based backbone terminated by t-butyl ester groups, providing hydrophilicity and a flexible spacer. It features ester linkages that can be selectively transformed under mild conditions, with ether-rich segments that enhance aqueous compatibility and reduce aggregation.
Reactivity: Suitable PROTAC assembly typically relies on ester-to-functional-group conversion or ester activation to enable formation of stable amide or related linkages with ligand-bearing nucleophiles. Common approaches use acid-mediated t-butyl ester deprotection to reveal carboxylic acid intermediates, followed by coupling chemistries such as carbodiimide-based activation in appropriate polar solvents. Reaction conditions should be optimized to preserve ligand integrity and minimize side reactions, with inert atmospheres and controlled pH often used to maintain selectivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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