5-(Biotinamido)pentylamine TFA salt
CAS No.: 288259-39-2
Cat No.: BP-502141
Purity: >97%
4.5 
5-(Biotinamido)pentylamine TFA salt is a biotin-derived primary amine linker featuring a biotinamide headgroup connected through a five-carbon spacer to an amino terminus, with trifluoroacetic acid forming a salt to improve handling and solubility. In PROTAC and targeted protein degradation designs, such biotinylated linkers are commonly used to introduce a high-affinity biotin handle that can be used to assemble ternary complexes or to conjugate biotin-binding modules, enabling controlled recruitment of biotin-recognizing partners while maintaining a defined linker length between functional domains. The flexible aliphatic chain and terminal amine support straightforward coupling to electrophilic groups (e.g., activated carboxylic acids or NHS-esters) to attach this linker to ligands, scaffolds, or reporter tags. As a modular building block, it facilitates systematic optimization of spatial arrangement and conjugation chemistry, which are critical determinants of degradation potency and selectivity in targeted protein degradation research.
Structure of 288259-39-2
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This PROTAC linker, supplied as a trifluoroacetate (TFA) salt, provides a biotinamide-bearing, flexible aliphatic connection point suitable for assembling targeted protein degraders via modular conjugation. Its design supports reliable coupling to affinity ligands and receptor-binding modules while maintaining conformational freedom that can improve productive ternary complex formation. The detailed Structure and Reactivity parameters are provided below for experimental planning.
Structure: The linker contains a saturated, flexible pentyl chain terminating in a primary amine, paired with a biotinamide functionality. Amide and multiple hydrogen-bonding sites are present, while the TFA counterion forms an ionic salt with the amine. Overall, it is a polar, water-compatible organic linker.
Reactivity: The primary amine enables standard PROTAC assembly strategies such as amide-bond formation using activated carboxylic acids (e.g., NHS/activated esters) or coupling reagents commonly used for amine–carboxyl conjugation. Reaction conditions are typically mild and compatible with biotin derivatives, often employing polar aprotic solvents and base to promote nucleophilic acyl substitution. The TFA salt can be neutralized in situ to improve coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
