Name: Boc-NH-PEG4-C2-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Synonyms

N-Boc-PEG4-t-butyl ester; 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1,17-bis(1,1-dimethylethyl) ester; 2-Methyl-2-propanyl 2,2-dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oate; 3,8,11,14,17-Pentaoxa-5-azaeicosan-20-oic acid, 2,2-dimethyl-4-oxo-, 1,1-dimethylethyl ester

Boiling Point

497.2±40.0°C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

HOBFRUPMGLPRSJ-UHFFFAOYSA-N

InChI

InChI=1S/C20H39NO8/c1-19(2,3)28-17(22)7-9-24-11-13-26-15-16-27-14-12-25-10-8-21-18(23)29-20(4,5)6/h7-16H2,1-6H3,(H,21,23)

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCOCCNC(=O)OC(C)(C)C

This Boc-protected PEG-based linker is designed for modular assembly of PROTACs, enabling reliable spacing and conformational flexibility between target-binding ligands. Its protected amine functionalities support controlled coupling strategies, helping researchers prepare degraders with reproducible architectures and minimized side reactions during synthesis. The details below describe its structural features and practical reactivity considerations for PROTAC construction.

Structure: The linker contains an oligo(ethylene glycol) segment providing hydrophilic, flexible spacing, flanked by Boc-protected amine termini. It features carbamate linkages from Boc groups and ether linkages within the PEG chain, yielding a polar, conformationally adaptable scaffold suitable for iterative amide or urea-forming chemistry.

Reactivity: Boc-protected amines are typically activated by acid-mediated deprotection to generate free amines, which then participate in standard PROTAC coupling reactions such as amide bond formation with activated carboxylic acids or acyl derivatives. Common approaches use coupling reagents and base in compatible organic solvents, while protecting-group stability should be maintained during ligand installation. Reaction design should follow established carbamate deprotection and amine-acylation principles to preserve linker integrity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂