Name: Boc-PEG5-methyl ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

methyl 3-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

InChI Key

BJNQNORQYFJOCD-UHFFFAOYSA-N

InChI

InChI=1S/C19H36O9/c1-19(2,3)28-18(21)6-8-24-10-12-26-14-16-27-15-13-25-11-9-23-7-5-17(20)22-4/h5-16H2,1-4H3

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCC(=O)OC

This flexible oligoether linker carries differentiated tert-butyl and methyl ester termini for sequential carboxyl unveiling. Their contrasting cleavage profiles facilitate directional attachment of amine-bearing ligands, making the spacer useful for modular, unsymmetrical PROTAC construction. Structural and reaction features follow.

Structure: A linear, ether-rich chain links tert-butyl and methyl propanoate groups. Its principal bonds include flexible carbon–oxygen and carbon–carbon single bonds plus ester carbonyls. The absence of free nucleophiles limits premature coupling, while the chemically differentiated termini enable staged activation.

Reactivity: Selective acidic cleavage can expose the tert-butyl-protected acid, whereas controlled ester hydrolysis can reveal the methyl-protected terminus. The resulting acid is suitable for carbodiimide-, phosphonium-, or uronium-mediated coupling with an amine in a dry polar aprotic solvent and base. Protecting-group order should be chosen after evaluating the acid and base tolerance of the recruited ligands.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂